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| Clinical observation of Dengzhan Shengmai Capsule in the treatment of cognitive impairment after ischemic stroke |
| Hits 57 Download times 7 Received:December 10, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2025.03.03 |
| Key Words
ischemic stroke;cognitive impairment;Dengzhan Shengmai Capsule;donepezil hydrochloride tablets |
| Author Name | Affiliation | E-mail | | RONG Xiaoting | Department of Traditional Chinese Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China | | | LIU Jun | Imaging Department, Tianjin Union Medical Center, Tianjin 300121, China
Imaging Department, Tianjin Fourth Central Hospital, Tianjin 300142, China | cjr.liujun@vip.163.com | | ZHUANG Tingyi | Department of Traditional Chinese Medicine, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China | | | LI Shumao | Department of Preventive Treatment, Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine, Tianjin 300120, Chian | | | LIU Xuehuan | Imaging Department, Tianjin Union Medical Center, Tianjin 300121, China | |
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| Abstract
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| [Objective] To observe the clinical effect of Dengzhan Shengmai Capsule combined with donepezil hydrochloride in the treatment of cognitive impairment after stroke. [Methods] A total of 100 patients with cognitive impairment after ischemic stroke were recruited，and they were divided into control group and treatment group，with 50 cases in each group. The baseline data of patients were collected，including demographic data，clinical data，cognitive assessment，assessment of daily living ability，laboratory examination results，and brain MRI imaging data. The control group was treated with donepezil hydrochloride，and the treatment group was treated with Dengzhan Shengmai Capsule combined with donepezil hydrochloride，and the treatment lasted for 3 months. The total effective rate of the two groups was evaluated before and after treatment. The clinical efficacy of two groups patients was evaluated by using montreal cognitive assessment scale（MoCA），MoCA index，modified Barthel index（MBI），the United States national institutes of health stroke scale（NIHSS），serum homocysteine（Hcy），serum hypersensitive c-reactive protein（hs-CRP） and the affected part of the value of the cerebral blood flow（CBF）. [Results] Compared with before treatment，the MoCA score，MoCA index（control group except visuospatial ability index，orientation index），MBI scores and rCBF of the two groups after treatment significantly increased（P＜0.05），NIHSS score，Hcy and experimental hs-CRP levels significantly decreased（P＜0.05）. The overall effective rate，improvement of MoCA scores，MoCA memory index，MoCA attention index，MoCA orientation index，MBI index，NIHSS score，and rCBF of the experimental group were better than that in control group，and the difference was statistically significant. Meanwhile，there were also significant differences in the reduction of Hcy level（P＜0.05）. [Conclusion] Dengzhan Shengmai Capsule combined with donepezil hydrochloride can effectively improve the cognitive function and neurological function scores of stroke patients，and improve the daily self-care ability of patients，which is better than donepezil hydrochloride alone. Meanwhile，the combination can improve cerebral blood flow，with high safety，which is worthy of clinical promotion and application. |
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