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| Identification of chemical constituents in Guanxinjing based on UPLC-Q-TOF-MS/MS technology |
| Hits 41 Download times 8 Received:December 09, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2025.03.12 |
| Key Words
Guanxinjing;ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry;chemical constituents;qualitative analysis |
| Author Name | Affiliation | E-mail | | LIU Yang | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIN Wenhan | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Wenwen | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | REN Hai | Baoding Traditional Chinese Medicine Pharmaceutical Co., Ltd., Anguo 071205, China | | | ZHAO Jiao | Baoding Traditional Chinese Medicine Pharmaceutical Co., Ltd., Anguo 071205, China | | | OUYANG Huizi | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | huihui851025@163.com | | HE Jun | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | hejun673@163.com |
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| Abstract
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| [Objective] To rapidly analyze and identify the chemical constituents of Guanxinjing. [Methods] Based on UPLC-Q-TOF-MS/MS technology，the chemical constituents in Guanxinjing were systematically characterized and identified by their characteristic fragments and neutral losses. [Results] A total of 96 major constituents including 29 terpenoids，29 organic acids，11 phthalides， 13 flavonoids，and 14 other constituents were identified by compared the accurate mass measurements and secondary mass spectrometry fragment ions，and combined with the literature report and the reference. [Conclusion] This method can quickly and accurately analyze the chemical constituents of Guanxinjing，which provides a theoretical basis for the quality control and pharmacodynamic substances research of Guanxinjing. |
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