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| Research progress of Tongmai Yangxin Pill and prediction analysis of quality marker（Q-marker） |
| Hits 54 Download times 8 Received:November 13, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2025.03.18 |
| Key Words
Tongmai Yangxin Pill;quality markers;chemical constituent;pharmacological effect |
| Author Name | Affiliation | E-mail | | ZHANG Yanyan | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | QIN Haoxue | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | YE Linxi | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | LE Nanxi | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | LIN Jiamei Hui | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | TANG Yi | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | CHEN Sixuan | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | HE Ruining | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | | | CHEN Ting | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China
Hunan Provincial Ministry of Traditional Chinese Medicine Powder and Innovative Drug Research Co-built National Key Laboratory Cultivation Base, Changsha 410208, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | 13920368971@163.com | | ZHANG Wei | College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
Hunan Key Laboratory of Integrated Chinese and Western Medicine for Prevention and Treatment of Heart and Brain Diseases, Changsha 410208, China | zhangwei1979@hnucm.edu.cn |
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| Abstract
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| Tongmai Yangxin Pill is a modern Chinese herbal medicine based on the addition and subtraction of traditional Chinese medicine prescriptions “Zhigancao Decoction” and “Shengmai Powder”，The main ingredients include Rehmannia glutinosa，licorice root，Codonopsis pilosula and other 11 traditional Chinese medicines. It is known for its effects in replenishing qi，nourishing yin，promoting blood circulation，and alleviating pain. Modern pharmacological studies have demonstrated that Tongmai Yangxin Pill has various pharmacological effects，including vasodilation，anti-inflammatory effects，protection of vascular endothelium，and inhibition of calcium overload. These properties make it widely applicable in the treatment of cardiovascular diseases，such as coronary artery disease，arrhythmias，and adverse reactions after percutaneous coronary intervention（PCI）. This review collected and summarized recent domestic and international research on the chemical composition，pharmacological effects，and clinical applications of Tongmai Yangxin Pill. Additionally，based on the “Five Principles” of traditional Chinese medicine quality markers（Q-markers），this paper predicted and analyzed the Q-markers of Tongmai Yangxin Pill. The results suggested that components such as Rehmannia glutinosa D，glycyrrhizin，glycyrrhetinic acid，glycyrrhizic acid，stilbene glycoside，emodin，schizandrin A，schizandrin B，schisandrin，ophiopogonin D，ruscogenin，gallic acid，and formononetin could serve as quality markers for Tongmai Yangxin Pill. These components can be selected for quality evaluation in future studies. This review aims to provide reference for improving the quality traceability system and quality evaluation and control system in the preparation process of Tongmai Yangxin Pill，in order to provide theoretical support for the clinical application of Tongmai Yangxin Pill. |
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