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| Formulation screening and preparation process optimization of betulin nanoemulsion |
| Hits 14 Download times 2 Received:November 01, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2025.04.13 |
| Key Words
betulin;nanoemulsion;formulation screening;preparation process |
| Author Name | Affiliation | E-mail | | WANG Dewang | College of Pharmacy, Harbin University of Commerce, Harbin 150076, China | | | MENG Tianchen | College of Pharmacy, Harbin University of Commerce, Harbin 150076, China | | | LI Xin | College of Pharmacy, Harbin University of Commerce, Harbin 150076, China | 102105@hrbcu.edu.cn |
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| Abstract
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| [Objective] To determine the process prescription for the preparation of Betulinol nano-emulsion. [Methods] Pseudo-ternary phase diagram method was used to screen the nano-emulsion prescription. The preparation process parameters were optimized using one-factor screening and effect surface method（Box-Behnken）. [Results] The optimal prescription of betulinol nano-emulsion was：m（isopropyl myristate）∶m（tween 80）∶m（glycerol）∶m（distilled water）=15.38%∶20.51%∶41.03%∶23.08%. The optimum prescription process was：stirring temperature 53 ℃，stirring speed 1 050 r/min，stirring time 6.2 min. [Conclusion] The determined prescription process was stable and simple，reproducible，and produced nanoemulsions with high drug loading capacity. |
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