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| Research progress of HIF-1α signaling pathway regulated by traditional Chinese medicine in the treatment of myocardial ischemia-reperfusion injury |
| Hits 20 Download times 1 Received:November 16, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2025.04.17 |
| Key Words
HIF-1α signaling pathway;traditional Chinese medicine;myocardial ischemia reperfusion injury;research progress |
| Author Name | Affiliation | E-mail | | LIU Yiman | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIA Huiyu | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG Wenshuai | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GUO Liuli | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIANG Feng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wecm@sina.com | | REN Ming | Baokang Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China | renming2008@126.com |
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| Abstract
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| Acute myocardial infarction can minimize myocardial ischemic damage and limit the infarct size by thrombolysis，drugs that dilate blood vessels，and percutaneous coronary intervention，but restoration of blood perfusion of ischemic myocardial tissue will lead to myocardial ischemia-reperfusion injury(MIRI). In recent years,it has found that traditional Chinese medicine(TCM) has the unique advantages of multi-component,multi-pathway and multi-target in the treatment of MIRI. Hypoxia-inducible factor 1 alpha(HIF-1α) plays an important role in promoting cell survival and recovery and reducing the degree of myocardial damage by regulating oxidative stress,inflammatory response,angiogenesis,apoptosis and autophagy during MIRI. Therefore,this paper summarized the relationship between HIF-1α signaling pathway and the pathogenesis of MIRI,as well as the current research progress of TCM in regulating HIF-1α signaling pathway to treat MIRI,in order to provide new ideas for the prevention and treatment of MIRI with TCM. |
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