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| Angong Niuhuang Pill in traditional Chinese medicine and Western medicine hospitals in real-world |
| Hits 759 Download times 244 Received:December 24, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2025.05.04 |
| Key Words
Angong Niuhuang Pill;real-world study;clinical application |
| Author Name | Affiliation | E-mail | | MENG Xiangran | Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
Qingdao Hospital of Traditional Chinese Medicine, Qingdao 266001, China | | | ZHU Xuesong | Beijing Massage Hospital, Beijing 100035, China | | | LIU Bo | Qingdao Hospital of Traditional Chinese Medicine, Qingdao 266001, China | | | CAO Xue | Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China | | | WANG Xin | Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China | | | HE Liyun | Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China | hely3699@163.com | | LIU Jia | Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China | marie_liujia@sina.cn |
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| Abstract
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| [Objective] To observe the clinical application of Angong Niuhuang Pill（ANP） in the hospital of traditional Chinese medicine（TCM） and Western medicine hospital through a prospective multi-center case registration study. [Methods] This study extracted 3 573 cases from 106 hospitals using ANP that met the inclusion and exclusion criteria in the EDC system，and divided them into TCM hospital group（38 hospitals） and Western medicine hospital group（68 hospitals） according to the nature of the hospitals. Excel and SPSS 25.0 were used to conduct a descriptive analysis of the general data and clinical treatment of the two groups of patients. Chi-square test and non-parametric test were used to compare the use of ANP and the condition assessment of patients before and after ANP. [Results] In terms of demographic characteristics，the median age of the two groups was 67 years old，the median BMI was 24.44 kg/m2，and the work was mainly non-physical，and most of them were male. In the TCM hospital group，the department of intensive care medicine was mainly（30.83%），and in the Western medicine hospital group，the department of neurosurgery was mainly（49.34%）. The attending physicians were the most in both groups. The proportion of patients with cerebral hemorrhage and acute ischemic stroke was about the same in the two groups，about 39%. In terms of ANP usage，from the perspective of administration methods，patients in the two groups mainly had oral and nasal feeding，with slightly more nasal feeding，and the difference was not statistically significant（P=0.742）. From the perspective of taking time，more than 98% of patients in both groups took it as prescribed by doctors. From the daily frequency of medication，two groups of patients took once a day accounted for the most，up to 5 times a day. In terms of ANP dosage，a single use was 0.75，1，1.5，2，3，6 g，of which 3 g is the most，that is，1 pill. In terms of the duration of ANP use，the median number of days in the TCM hospital group was 2 d，and the median number of days in the Western medicine hospital group was 3 d. In terms of ANP administration time，the average time after the onset of ANP was（5.13±10.93） days in TCM hospital group and（3.42±7.01） days in Western medicine hospital group. In combination with Western medicine，the proportion of neuroprotective agents in both groups were the highest. In terms of other treatments，acupuncture and physical therapy were more common in the TCM hospital group，while surgery was more common in the Western medicine hospital group. In terms of improving patients’ condition，mRS scores and NIHSS scores were decreased and BI scores were increased in both groups after taking ANP（P＜0.05）. For the patients with consciousness disorder，GCS scores were increased in both groups after taking ANP（P＜0.05）. For patients with cognitive impairment，MMSE scores were increased in both groups after taking ANP（P＜0.05）. For the patients with high fever，the duration of fever remission was（5.27±3.11） days in the TCM hospital group and（5.12±4.18） days in the Western medicine hospital group. During the whole course of treatment，8 patients in both groups had adverse events，but no serious adverse events occurred. [Conclusion] Based on the actual clinical diagnosis and treatment data of ANP，this study finds that most patients in the two groups of TCM hospital and Western medicine hospital are elderly males，and most of them are overweight. The clinical application of ANP is mainly for apoplexy，and the application basically conforms to the drug instructions，and there are off-instructions. The use of ANP in both TCM and Western medicine hospitals can achieve certain curative effects. |
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