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| Acupuncture combined with different mecobalamin injection methods for diabetic peripheral neuropathy： A network Meta-analysis |
| Hits 807 Download times 266 Received:February 18, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.06.11 |
| Key Words
diabetic peripheral neuropathy;acupuncture;mecobalamin injection;Bayes Theorem;network Meta-analysis |
| Author Name | Affiliation | E-mail | | ZHU Wenyan | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | ZHAN Yijun | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | PEI Jian | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | longhuaacup@aliyun.com | | WANG Ruiqi | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | LIN Shiyu | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | GUAN Qingyang | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | ZHU Like | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | LIU Shaogui | Acupuncture Department Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | |
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| Abstract
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| [Objective] This study aimed to systematically evaluate the efficacy and safety of acupuncture combined with different Mecobalamin Injection methods in treating diabetic peripheral neuropathy（DPN）. [Methods] A computer search of PubMed，Web of Science，EMbase，Cochrane Library，China National Knowledge Infrastructure（CNKI），VIP Chinese Sci-Tech Journal Database（VIP），China Biology Medicine disc，and Wanfang Academic Journal Full-text Database was conducted for randomized controlled trials（RCTs） on acupuncture and/or mecobalamin injection for the treatment of DPN. A Bayesian framework was used for network Meta-analysis. [Results] Fifty four RCTs with a total of 4 236 patients were included in this study. Among nine interventions，acupuncture plus acupoint injection of mecobalamin plus usual treatment（AC+AIM+UT） was the most effective in improving overall response rate（93.55%），median sensory nerve conduction velocity（SCV，91.63%），and peroneal SCV（98.72%）. In terms of improvement in median motor nerve conduction velocity（MCV） and peroneal MCV，acupoint injection of mecobalamin plus usual treatment（AIM+UT） was the best therapy（81.70% and 79.85%，respectively）. The most common adverse events included skin rashes，nausea，vomiting，arrhythmia，and sweating. More adverse events occurred in patients treated by intravenous injection of mecobalamin. [Conclusion] AC+AIM+UT is the preferred therapy for improving overall response rate and sensory nerve conduction velocity，while AIM+UT is the treatment of choice for improving motor nerve conduction velocity. |
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