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| Clinical efficacy of Naoxueshu Oral Liquid on patients with acute cerebral hemorrhage and its effects on neurological function and activities of daily living |
| Hits 287 Download times 97 Received:August 25, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.12.03 |
| Key Words
acute cerebral hemorrhage;Naoxueshu Oral Liquid;clinical efficacy;neurological function;activities of daily living |
| Author Name | Affiliation | E-mail | | CHE Siyao | Department of Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China | | | WANG Haifang | Department of Geriatrics, Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100102, China | | | CHE Siyu | Nursing Department, Shanxi Bethune Hospital, Taiyuan 030032, China | | | DU Peipei | Department of Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China | | | ZHONG Dixiang | Department of Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China | | | HAO Yunlong | Department of Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China | | | CHEN Bei | Department of Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China | | | GUO Dingyuan | Department of Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China | | | KONG Lingbo | Department of Brain Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100070, China | klb1984@163.com |
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| Abstract
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| [Objective] To explore the clinical efficacy of Naoxueshu Oral Liquid in patients with acute intracerebral hemorrhage and its impact on neurological function and activities of daily living. [Methods] A total of 398 patients with acute intracerebral hemorrhage treated at multiple centers from April 2023 to April 2025 were selected. Based on the treatment plan，they were divided into the observation group（250 cases） and the control group（148 cases）. The control group received routine symptomatic treatments，including intracranial pressure reduction，sedation，and oxygen therapy. The observation group received Naoxueshu Oral Liquid in addition to the treatment provided to the control group. Both groups were followed up for 3 months. The clinical efficacy，neurological function，and activities of daily living were compared between the two groups，and the incidence of adverse events was recorded. [Results] The clinical efficacy rate of the observation group was 88.80%，higher than that of the control group（80.41%），P＜0.05. At 7 and 14 days post-onset，the National Institutes of Health Stroke Scale（NIHSS） scores of both groups were lower than those before onset，with the observation group showing lower scores than the control group（P＜0.05）. At 14 days post-onset，both groups had lower NIHSS scores compared to the scores at 7 days post-onset，with the observation group again having lower scores than the control group（P＜0.05）. At 1 and 3 months post-onset，the modified Rankin Scale（mRS） scores of the observation group were lower than those of the control group（P＜0.05）. At 1 and 3 months post-onset，both groups had improved scores on the Barthel Index（BI） compared to the 14-day scores（P＜0.05）. At 3 months post-onset，both groups had increased BI scores compared to 1 month post-onset（P＜0.05）. The BI scores of the observation group were higher than those of the control group at 14 days，1 month，and 3 months post-onset（P＜0.05）. Over time，both groups showed a gradual increase in the Mini-Mental State Examination（MMSE） scores，but there were no statistically significant differences（P>0.05）. However，at 14 days，1 month，and 3 months post-onset，the MMSE scores of the observation group were higher than those of the control group（P＜0.05）. No deaths were reported in either group during the 3-month follow-up period. The incidence of adverse reactions in the observation group was 6.00%，significantly lower than the 14.86% in the control group（P＜0.05）. [Conclusion] Naoxueshu Oral Liquid is effective for patients with acute intracerebral hemorrhage，with significant improvement in clinical efficacy，neurological function，activities of daily living，and cognitive function. It also demonstrates good safety. |
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