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| Effects of Jinlida Granule combined with polyethylene glycol loxenatide on endothelial function and AGEs levels in patients with diabetic kidney disease of qi and yin deficiency type |
| Hits 302 Download times 112 Received:September 12, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.12.04 |
| Key Words
Jinlida Granule;polyethylene glycol loxenatide;diabetic kidney disease;endothelial function |
| Author Name | Affiliation | E-mail | | ZHAO Congcong | Endocrinology Department I, Baoding First Central Hospital, Baoding 071000, China | | | YIN Zhonglai | Endocrinology Department I, Baoding First Central Hospital, Baoding 071000, China
Diabetes Department IV, Cangzhou Integrated Traditional and Western Medicine Hospital, Cangzhou 061000, China | | | ZHANG Qian | Diabetes Department IV, Cangzhou Integrated Traditional and Western Medicine Hospital, Cangzhou 061000, China | feifan202502@163.com |
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| Abstract
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| [Objective] To explore the impacts of joint of Jinlida Granule and polyethylene glycol loxenatide on endothelial function and advanced glycation end products （AGEs） in patients with diabetic kidney disease （DKD） with qi and yin deficiency symptom. [Methods] Totally 105 patients with qi and yin deficiency type DKD in Cangzhou Integrated Traditional and Western Medicine Hospital were assigned into control group of 52 cases and treatment group of 53 cases randomly （from January 2024 to January 2025）. Both groups were given regular treatment，while the control group adopted polyethylene glycol loxenatide，and the treatment group adopted Jinlida Granule on the top of control group. Two groups were compared in terms of endothelial function，AGEs，human monocyte chemoattractant protein-1 （MCP-1），Chinese medicine syndrome score，blood glucose，and renal function. [Results] After treatment，the nitric oxide （NO） increased in both groups，with the treatment group having a higher level （P＜0.05）. The levels of endothelin-1 （ET-1），AGEs，MCP-1，traditional Chinese medicine syndrome scores of dizziness，fatigue，dry throat and dry mouth，fasting plasma glucose （FPG），2 h postprandial blood glucose （2 h PG），blood urea nitrogen （BUN），serum creatinine （Scr） and 24-hour urinary protein quantificationwere decreased in the two groups，and the treatment group was lower than the control group （P＜0.05）. [Conclusion] The joint of Jinlida Granule and polyethylene glycol loxenatide in treating qi and yin deficiency type DKD can improve vascular diastolic function，reduce vascular resistance，and enhance vascular function. It can also improve renal microcirculation，reduce renal inflammatory response，and alleviate renal damage. |
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