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| Clinical comparative study on different traditional Chinese medicine syndromes of mycoplasma pneumoniae pneumonia in children |
| Hits 289 Download times 100 Received:October 14, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.12.06 |
| Key Words
mycoplasma pneumoniae pneumonia;children;wind-heat obstructing the lung syndrome;phlegm-heat obstructing the lung syndrome;toxic-heat obstructing the lung syndrome;damp-heat obstructing the lung syndrome |
| Author Name | Affiliation | E-mail | | WANG Yi | Department of Pediatrics, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300100, China | | | LIU Yan | Department of Pediatrics, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300100, China | liuyan021440@126.com | | WANG Zhihua | Department of Pediatrics, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300100, China | |
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| Abstract
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| [Objective] To compare the differences in symptoms，signs and laboratory tests of children with mycoplasma pneumoniae pneumonia（MPP） with different traditional Chinese medicine（TCM） syndromes，so as to provide reference and basis for clinical accurate differentiation and treatment of MPP. [Methods] A total of 156 children with MPP who were diagnosed in the Department of Pediatrics of Tianjin Hospital of ITCWM Nankai Hospital from November 2023 to September 2024 were collected as subjects. According to TCM syndrome differentiation，they were divided into wind-heat obstructing the lung syndrome，phlegm-heat obstructing the lung syndrome，toxic-heat obstructing the lung syndrome，and damp-heat obstructing the lung syndrome. General information（gender，age，height，weight，disease course，etc.），symptoms and signs [days of fever and cough，drug resistance，enhanced respiratory sounds，glucocorticoid use，chest computed tomography（CT） findings，etc.]，and laboratory parameters（complete blood count，C-reactive protein，immunological tests，liver and kidney function，serum amyloid A，D-dimer，lactate dehydrogenase，etc.） were compared across these syndrome groups. [Results] Among the 156 children with MPP，there were 47 cases of wind-heat obstructing the lung syndrome，60 cases of phlegm-heat obstructing the lung syndrome，34 cases of toxic heat obstructing the lung syndrome and 15 cases of damp-heat obstructing the lung syndrome. The course of disease in children with damp-heat obstructing the lung syndrome was the longest，and the difference was statistically significant compared with the other three groups（P＜0.05 or P＜0.01）. The fever time of children with phlegm-heat obstructing the lung syndrome，toxic-heat obstructing the lung syndrome and damp-heat obstructing the lung syndrome was longer than that of children with wind-heat obstructing the lung syndrome，and toxic-heat obstructing the lung syndrome was longer than that of phlegm-heat obstructing the lung syndrome（P＜0.05 or P＜0.01）. The cough time of children with damp-heat obstructing the lung syndrome was longer than that of the other three groups（P＜0.05 or P＜0.01）. The use rate of glucocorticoids in children with phlegm-heat obstructing the lung syndrome，toxic heat obstructing the lung syndrome and damp-heat obstructing the lung syndrome was higher than that in wind-heat obstructing the lung syndrome（P＜0.05）. In the results of CT in children with wind-heat obstructing the lung syndrome，the number of lung texture thickening was more than that of toxic-heat obstructing the lung syndrome（P＜0.05）. The count of killer T cells in MPP children with damp-heat obstructing the lung syndrome was higher than that in the other three groups（P＜0.05 or P＜0.01）. The NK cell count in children with toxic heat obstructing the lung syndrome was higher than that in children with phlegm heat obstructing the lung syndrome（P＜0.05）. The neutrophil count in children with toxic heat obstructing the lung syndrome was higher than that in children with phlegm heat obstructing the lung syndrome（P＜0.05）. The immunoglobulin G of children with damp-heat obstructing the lung syndrome was lower than that of wind-heat obstructing the lung syndrome and phlegm-heat obstructing the lung syndrome（P＜0.05）. The C-reactive protein in children with toxic heat obstructing the lung syndrome was higher than that in phlegm-heat obstructing the lung syndrome and lower than that in damp-heat obstructing the lung syndrome（P＜0.05）. Serum amyloid A in children with toxic heat obstructing the lung syndrome was higher than that in wind-heat obstructing the lung syndrome and damp-heat obstructing the lung syndrome（P＜0.05）. The CD4+/CD8+ in the phlegm-heat obstructing the lung syndrome group was higher than that in the wind-heat obstructing the lung syndrome group（P＜0.05）. [Conclusion] MPP children with different TCM syndromes have differences in course of disease，duration of fever，duration of cough，glucocorticoid use rate，CT reports，killer T cell count，NK cell count，neutrophil count，immunoglobulin G，C-reactive protein，serum amyloid A，CD4+/CD8+，suggesting that clinical treatment can be based on the above symptoms，signs or laboratory indicators combined with traditional Chinese medicine syndrome differentiation methods to improve the efficiency，accuracy and therapeutic effect of syndrome differentiation. |
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