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| A preliminary study on the integrated traditional Chinese and Western medicine precise syndrome differentiation typing in PCOS patients |
| Hits 330 Download times 99 Received:September 22, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.12.07 |
| Key Words
PCOS;precise syndrome differentiation;body fat percentage;metabolism;hormones |
| Author Name | Affiliation | E-mail | | LIN Kaili | Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | SONG Dianrong | Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | songdr58@126.com | | WANG Jiaojian | Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | SUN Yue | Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHANG Wei | Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LU Di | Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | |
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| Abstract
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| [Objective] To establish a precise traditional Chinese medicine（TCM） syndrome differentiation standard for polycystic ovary syndrome（PCOS） based on the integration of four diagnostic methods（inspection，auscultation and olfaction，inquiry，and palpation），body fat percentage，and serum biomarkers，with obesity as the entry point and body fat content and distribution as the foundation. [Methods] Clinical data and traditional Chinese medicine diagnostic information were collected from PCOS patients attending the gynecology outpatient clinic at the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine between January 2023 and December 2023. The distribution characteristics of traditional Chinese medicine syndrome types in PCOS were summarized，and the clinical features and biological indicators of different traditional Chinese medicine syndrome types were compared. [Results] A total of 393 PCOS patients were included in this study. The most prevalent traditional Chinese medicine syndrome was spleen deficiency with phlegm-dampness（218 cases，55.22%），followed by kidney yin deficiency（151 cases，38.42%）. Analysis of the relationship between BMI and body fat percentage revealed that while the majority of patients with high BMI also had high body fat（92.37%），a considerable proportion of high-BMI patients（20.73%） were found to have low body fat. Conversely，a significant subset of patients with low BMI（36.31%） had high body fat. Among both obese and non-obese PCOS patients with spleen deficiency and phlegm-dampness syndrome，high body fat was the predominant feature. Conversely，in both obese and non-obese PCOS patients with kidney yin deficiency syndrome，low body fat was the primary characteristic. Patients with spleen deficiency and phlegm-dampness syndrome showed significantly higher body mass index（BMI），body fat percentage，waist-to-hip ratio，hirsutism incidence，and acne incidence compared to those with kidney yin deficiency（P＜0.05）. Serum biomarkers，including TSH，FPG，FINS，HOMA-IR，LAP，and VAI，were also significantly elevated（P＜0.05），while LH，LH/FSH ratio，and HDL-C levels were significantly lower（P＜0.05）. [Conclusion] The primary traditional Chinese medicine syndrome types of PCOS are spleen deficiency with phlegm-dampness and kidney yin deficiency. Body fat percentage may serve as a distinctive marker for these syndromes. Patients with spleen deficiency and phlegm-dampness exhibit more severe metabolic disturbances，whereas those with kidney yin deficiency demonstrate characteristic hyperactivity of the hypothalamic-pituitary axis. The combination of body fat percentage with hormonal and metabolic indicators provides an objective basis for the precise syndrome differentiation of PCOS. |
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