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| Differentiation of diabetic renal disease from spleen and kidney based on gut-kidney axis theory |
| Hits 329 Download times 97 Received:August 23, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2025.12.09 |
| Key Words
diabetic kidney disease;gut-kidney axis;intestinal microecology;traditional Chinese medicine;in-hospital preparation |
| Author Name | Affiliation | | ZHU Changhao | First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | LI Hengda | First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | ZHANG Tao | First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | TANG Ge | First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | XING Haitao | First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | MA Leilei | First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China |
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| Abstract
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| To explore the connotation of the gut-kidney axis theory and its relationship with diabetic kidney disease（DKD），this paper presents a traditional Chinese medicine perspective on the treatment of DKD from the perspective of spleen and kidney. Combining the latest research progress of both traditional Chinese medicine and Western medicine，this paper analyzes the gut-kidney axis theory and elucidates its mechanism of participation in the development of DKD. It also briefly discusses the traditional Chinese medicine differentiation and treatment principles and strategies. The pathological key of DKD is spleen and kidney deficiency and intestinal function disorder. Traditional Chinese medicine not only can supplement spleen and kidney，support the body and dispel pathogenic factors，but also can restore intestinal function by regulating intestinal microflora，repairing intestinal barrier and correcting abnormal intestinal metabolism. Clinical studies often achieve significant therapeutic effects. The gut-kidney axis is closely related to the development of DKD. In clinical practice，the spleen and kidney are regulated together to treat the root cause，with restoring intestinal function as the main goal. Improving intestinal microecology is the key to preventing and slowing the progression of DKD. Based on the gut-kidney axis theory，traditional Chinese medicine treatment of this disease provides a new perspective on diagnosis and treatment and theoretical basis. |
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