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| Analysis of the registration characteristics of clinical trials on migraine treated with traditional Chinese medicine |
| Hits 249 Download times 89 Received:June 26, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.12.11 |
| Key Words
migraine;traditional Chinese medicine therapy;clinical trial registration;characteristics analysis |
| Author Name | Affiliation | E-mail | | LIU Xueying | Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China
Beijing University of Chinese Medicine, Beijing 100029, China | | | SU Dune | Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | | | WANG Honghong | Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | | | ZHANG Shuhan | Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | | | SUN Yihan | Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | | | GUO Xiongbo | Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | | | ZHAO Yonglie | Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | yongy3@126.com |
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| Abstract
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| [Objective] To explore the registration characteristics and development trends of clinical trials on the prevention and treatment of migraine with traditional Chinese medicine. [Methods] The information on clinical trials related to the treatment of migraine with Chinese medicine was searched and extracted from the Chinese Clinical Trial Registry，the U.S. Clinical Trial Registry，and the International Traditional Medicine Clinical Trial Registry Platform from the date of establishment of the respective databases until April 22，2025. Descriptive statistical analysis was adopted. Count data were statistically described by frequency and percentage（n，%）. [Results] A total of 88 clinical trials on migraine treated with traditional Chinese medicine were included. Most of the registered trials were interventional studies（83，94.3%），and a randomized parallel-controlled design was predominantly used（73，83.0%）. The study population primarily consisted of patients with migraine without aura（39，44.3%）. Interventions were mainly categorized into internal Chinese medicine treatments（19，21.6%），external Chinese medicine treatments（63，71.6%），and combined internal and external treatments（6，6.8%），with acupuncture being the most common（52，59.1%）. The most frequently used primary outcome indicators（>10 studies） were，in descending order：headache attack frequency，number of headache days，magnetic resonance imaging indices，and the visual analog scale score. [Conclusion] The number of registered clinical trials on migraine treated with traditional Chinese medicine continues to grow. However，the standardization of registration information needs improvement，suggesting that researchers should strictly adhere to international registration standards when completing registration details. |
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