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| Metabolomic analysis of the protective effect and potential mechanism of Shengmai Capsules on the liver of mice undergoing 5-fluorouracil chemotherapy |
| Hits 250 Download times 102 Received:June 30, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.12.15 |
| Key Words
chemotherapy-induced liver injury;Shengmai Capsules;nuclear magnetic resonance;metabolomics |
| Author Name | Affiliation | E-mail | | GONG Zuyan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Zhaodong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Dian | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Shuwu | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MIAO Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Liming | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HAN Lifeng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YAN Hao | Nankai University Affiliated People's Hospital, Tianjin 300121, China | | | XU Yanjie | The Third Central Hospital of Tianjin, Tianjin 300170, China | xuyanjie70582@163.com | | PENG Yanfei | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | pengyanfei@tjutcm.edu.cn |
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| Abstract
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| [Objective] To explore the protective effect and molecular mechanism of Shengmai Capsules on chemotherapy-induced liver injury of mice. [Methods] The body weight，liver weight and liver index of mice in the control group，chemotherapy group and chemotherapy combined with Shengmai Capsules group were recorded and compared. Serum activities of alanine aminotransferase（ALT） and aspartate aminotransferase（AST） were detected and liver tissues were examined by pathomorphology. Proton nuclear magnetic resonance（1H-NMR） metabolomics were performed to analyze differential metabolites in liver and to investigate the possible role and mechanism of Shengmai Capsules in alleviating chemotherapy-induced liver injury. [Results] chemotherapy combined with Shengmai Capsules treatment significantly reversed the decrease in body weight，liver weight and liver index caused by chemotherapy，and downregulated serum AST activity，as well alleviated edema and eosinophilic changes in liver tissues. Metabolomic analysis showed that combined treatment with chemotherapy and Shengmai Capsule elevates the levels of taurine，glutamine，and melatonin in mice liver. These metabolites were mainly enriched in glucose metabolism pathway and amino acid metabolism pathways. [Conclusion] Shengmai Capsules can alleviate chemotherapy-induced liver injury in mice by regulating glucose metabolism and amino acid metabolism pathways |
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