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| Research progress on Gegen Qinlian Decoction in treating diarrhea-predominant irritable bowel syndrome |
| Hits 209 Download times 87 Received:September 15, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.12.19 |
| Key Words
Gegen Qinlian Decoction;irritable bowel syndrome;pharmacological mechanisms;review |
| Author Name | Affiliation | E-mail | | WEN Shunyao | Hebei University of Chinese Medicine, Shijiazhuang 050200, China
The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China | | | WANG Zhikun | Hebei University of Chinese Medicine, Shijiazhuang 050200, China
The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China
Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research in Hebei Province, Shijiazhuang 050011, China | wzk1529@126.com |
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| Abstract
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| Diarrhea-predominant irritable bowel syndrome（IBS-D） is a common functional bowel disease in clinical practice. As a classic formula，Gegen Qinlian Decoction acts to elevate spleen-yang，fortify the spleen，clear heat，resolve dampness，and ascend the clear while descending the turbid. Modern pharmacological research has demonstrated that this formula exerts its therapeutic effects through various mechanisms，including regulating gut microbiota，protecting the intestinal barrier，exerting multi-target anti-inflammatory actions，and modulating immune balance. Current clinical studies have shown that Gegen Qinlian Decoction，either used alone or in combination with other therapies，can alleviate symptoms，improve the quality of life，and has a favorable safety profile in patients with IBS-D. |
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