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| Discussion on the biological connotation of“spleen corresponding to late summer”based on the pathogenesis of ulcerative colitis in late summer |
| Hits 292 Download times 82 Received:August 15, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.01.11 |
| Key Words
spleen corresponding to late summer;ulcerative colitis;macrophage;ROS/HIF-1α |
| Author Name | Affiliation | E-mail | | HE Xue | Beijing University of Chinese Medicine, Beijing 100029, China | | | SUN Yike | Beijing University of Chinese Medicine, Beijing 100029, China | | | LIU Leilei | Beijing University of Chinese Medicine, Beijing 100029, China | lightloving@126.com |
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| Abstract
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| The aberrant intestinal flora in the season of late summer can mediate the macrophages M1/M2 polarization imbalance of macrophages through ROS/HIF-1α pathway，thus inducing the occurrence of ulcerative colitis（UC）. Based on the pathogenesis of UC in the season of late summer，this paper discusses the biological connotation of“spleen corresponding to late summer”，in order to clarify the biological essence of“spleen corresponding to late summer”and reveal the scientific connotation of“correspondence between man and universe”. In addition，the imbalance mechanism of the regulatory chain of“intestinal microbiota-ROS/HIF1αmacrophage M1/M2 polarization”provides a new diagnosis and treatment target for the prevention and treatment of seasonal UC. |
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