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| The regulatory mechanism of multimodal death of neutrophils in the pathological process of sepsis |
| Hits 266 Download times 62 Received:August 05, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.01.18 |
| Key Words
neutrophil death;sepsis;necrosis;apoptosis;autophagy;pyroptosis;NETosis;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | GENG Ziyao | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHU Rongli | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Shiqi | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GONG Boyang | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Ying | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | BIAN Yuhong | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | bianyuhong_2012@163.com | | JIA Beitian | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | 605442562@qq.com |
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| Abstract
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| Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection. Neutrophils，as the first line of innate immune defense，play a critical role in combating infections through phagocytosis of pathogens，release of inflammatory cytokines，reactive oxygen species（ROS），and antimicrobial substances. The regulation of neutrophil death modes is also closely linked to the pathological progression of sepsis. In the context of sepsis，neutrophil apoptosis is significantly inhibited，leading to abnormal prolongation of their lifespan，accompanied by impaired migration capacity and a potential shift toward other forms of cell death，such as necroptosis and NETosis，thereby exacerbating inflammatory responses and tissue damage. This article systematically reviews the known impacts of multimodal neutrophil death modes on the development of sepsis and the research progress in traditional Chinese medicine（TCM）strategies targeting neutrophils for sepsis treatment. The aim is to provide new theoretical perspectives and research directions for elucidating the pathophysiological characteristics of sepsis and developing targeted therapeutic strategies. |
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