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| Research progress on the regulatory mechanism of PGC-1α in diabetic kidney disease and the intervention of traditional Chinese medicine |
| Hits 222 Download times 77 Received:July 09, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.01.19 |
| Key Words
PGC-1α;diabetic kidney disease;traditional Chinese medicine;mechanism of action;research progress |
| Author Name | Affiliation | E-mail | | HE Yifan | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Jiaqi | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | FU Bin | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | fubin5393@126.com | | WANG Lijun | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | |
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| Abstract
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| Diabetic kidney disease（DKD）is one of the most common and severe microvascular complications of diabetes，with a complex pathogenesis. Current treatment methods are difficult to effectively halt its progression and often have limitations. In recent years，research has found that peroxisome proliferator-activated receptor（PPAR）γ coactivator-1α（PGC-1α）plays a significant role in regulating blood glucose，mitophagy，oxidative stress，inflammatory responses，apoptosis，and improving renal fibrosis，all closely related to the progression of DKD. Traditional Chinese medicine can delay the progression of DKD by regulating the expression of PGC-1α through multiple targets and pathways. Therefore，this article systematically reviews the mechanisms of PGC-1α in DKD and summarizes the research progress on traditional Chinese medicine targeting PGC-1α to intervene in DKD，aiming to provide new insights for the treatment of DKD. |
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