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| Clinical study on changes of tongue coating cicrobiota in patients with coronary heart disease and angina pectoris of qi-stagnation and blood stasis syndrome treated with Xuefu Zhuyu Capsule |
| Hits 260 Download times 31 Received:November 07, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.02.04 |
| Key Words
coronary heart disease-related angina pectoris;qi-stagnation and blood-stasis syndrome;Xuefu Zhuyu Capsule;tongue coating microbiota |
| Author Name | Affiliation | E-mail | | ZHANG Qian | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HE Yuanyuan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHEN Wenli | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Shuo | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Shan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | NI Tongyao | Shanghai Medical Emergency Center, Shanghai 200233, China | 15822309511@163.com | | YU Chunquan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | ycqtjutcm@foxmail.com |
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| Abstract
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| [Objective]This study employed 16S rDNA sequencing technology to investigate the effects of Xuefu Zhuyu Capsules on the tongue coating microbiota in patients with coronary heart disease-related angina pectoris(qi-stagnation and blood-stasis syndrome), providing experimental evidence for its clinical application.[Methods]A prospective, multicenter clinical trial design was adopted. Patients with coronary heart disease and angina pectoris of qi-stagnation and blood stasis pattern were divided into the Xuefu Zhuyu Capsule treatment group(Xuefu Zhuyu Capsules combined with conventional Western medicine treatment), the conventional Western medicine treatment group, and a healthy control group, with 30 cases in each group. Tongue coating samples were collected at 0 week and 8 week from the two treatment groups, and at week 0 from the healthy group. 16S rDNA amplicon sequencing was used to profile the tongue coating microbiota in patients with coronary heart disease and angina pectoris of qi-stagnation and blood stasis syndrome, in order to identify disease-related taxa and key microbiota modulated by Xuefu Zhuyu Capsules.[Results]Compared with healthy individuals, patients showed increased enrichment of Proteobacteria and Actinobacteria, which decreased after Xuefu Zhuyu Capsules treatment. Conversely, reduced enrichment of Bacteroidetes, Firmicutes and Fusobacteria was observed, with their abundance increasing post-treatment. LEfSe analysis identified Roseburia, Micrococcaceae, Micrococcales, Actinobacteria and Actinomyces as biomarkers regulated by Xuefu Zhuyu Capsules.[Conclusion]Xuefu Zhuyu Capsules alleviate clinical symptoms in patients with coronary heart disease and angina pectoris(qi-stagnation and blood stasis syndrome), accompanied by tongue coating flora structural alterations and suggested the flora may serve as a potential microcosmic indicator for evaluating the drug's efficacy in this condition. |
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