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| Study on the clinical efficacy and neural plasticity mechanism of acupuncture combined with repetitive transcranial magnetic stimulation in improving motor dysfunction after cerebral infarction |
| Hits 295 Download times 43 Received:October 25, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.02.05 |
| Key Words
cerebral infarction;acupuncture;repetitive transcranial magnetic stimulation;motor dysfunction;neural plasticity |
| Author Name | Affiliation | | WANG Shan | Nanyang Central Hospital of Nanyang City Henan Province, Nanyang 473000, China | | WANG Fan | Nanyang Central Hospital of Nanyang City Henan Province, Nanyang 473000, China |
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| Abstract
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| [Objective]To explore the clinical efficacy of acupuncture combined with rTMS in improving motor dysfunction after AIS and its neural plasticity mechanism.[Methods]The 160 patients with AIS postoperative motor dysfunction admitted from March 2022 to March 2025 were selected and randomly divided into two groups using a random number table method. The control group(80 cases) was treated with rTMS, and the combined group(80 cases)was simultaneously treated with acupuncture therapy on the basis of the control group. The scores of the Fugl-Meyer Motor Function Scale(FMA), Berg Balance Scale(BSS), Holden Functional Walking Scale (FAC), 6-minute Walk Test(6MWT), and Barthel Index(BI)were compared between the two groups. Analyze the correlation between the recovery of motor function and cerebral hemodynamic indicators, neurobiochemical indicators and neuroelectrophysiological indicators.[Results]After treatment, the FMA score, BSS score, FAC grade, 6MWT, and BI score of the combined group were higher than those of the control group(P < 0.05). After treatment, the blood flow velocities of the middle cerebral artery, basilar artery, and vertebral artery in the combined group were higher than those in the control group(P < 0.05). After treatment, the BDNF and NGF in the combined group were higher than those in the control group(P < 0.05). After treatment, the amplitude of MEP in the combined group was higher than that in the control group, and the latency was lower than that in the control group(P < 0.05). Relevant analysis showed that the FMA score of AIS patients was positively correlated with the blood flow velocities of the middle cerebral artery, basilar artery and vertebral artery(r=0.642, 0.493, 0.475, all P < 0.001). The FMA score was positively correlated with the levels of BDNF and NGF(r =0.450, 0.464;P < 0.001). The FMA score was Positively correlated with the amplitude(r=0.718, P < 0.001)and negatively correlated with the latency of MEP(r=-0.736, P < 0.001).[Conclusion]Acupuncture combined with rTMS can effectively improve motor dysfunction after AIS. Improving cerebral hemodynamics, promoting the expression of neurotrophic factors, and stimulating the activity of the motor cortex may be the main mechanisms by which it improves neural plasticity. |
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