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| Meta-analysis of kidney-tonifying and blood-activating formula in the treatment of knee osteoarthritis and data mining of herbal prescriptions |
| Hits 375 Download times 37 Received:December 15, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.02.09 |
| Key Words
kidney-tonifying and blood-activating;knee osteoarthritis;Meta-analysis;data mining;Chinese herbal medicine |
| Author Name | Affiliation | E-mail | | DU Chao | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | YANG Jialin | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | CHEN Ruisi | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | ZHONG Jiwei | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | CAO Dongdong | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | GUO Tianci | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | WU Weiyong | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | LIU Aifeng | Department of Orthopedics and Traumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | Draifeng163.com |
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| Abstract
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| [Objective]To systematically evaluate the efficacy and safety of oral kidney-tonifying and blood-activating Chinese herbal formulas in treating knee osteoarthritis(KOA), and to explore the prescribing patterns.[Methods]Randomized controlled trials (RCTs)published between January 2015 and April 2025 were retrieved from eight databases including CNKI, Wanfang Database, and PubMed. Studies meeting the inclusion criteria were screened, and data were extracted for Meta - analysis. Statistical analysis was performed using RevMan 5.4 and Stata 17.0 software. Outcomes such as total effective rate, WOMAC score, VAS score, Lequesne index, and adverse events were pooled. Additionally, frequency analysis, property-flavor-meridian distribution, association rule analysis, and cluster analysis were conducted on the included herbal prescriptions.[Results]A total of 14 RCTs involving 1 198 patients were included. The meta-analysis showed that kidney-tonifying and blood-activating herbal formulas were superior to conventional Western medicine in terms of total effective rate [OR=2.58, 95%CI(1.87, 3.57)], WOMAC score[OR=-2.64, 95%CI(-3.96, -0.96)], VAS score[OR=-0.63, 95%CI(-0.85, -0.42)], and Lequesne index[OR=-1.09, 95%CI(-1.37, -0.80), P < 0.05], with no significant difference in adverse events[OR=0.60, 95%CI(0.25, 1.34), P=0.25]. Data mining revealed that high - frequency herbs included Achyranthes bidentata, Rehmannia glutinosa and Angelica sinensis. Herbal properties were primarily warm and neutral, and meridians were mainly linked to the liver, kidney, and spleen. The core herb pair was Achyranthes bidentata and Spatholobus suberectus(confidence 100%).[Conclusion]When used alone, kidney-tonifying and blood-activating Chinese herbal formulas demonstrate a superior trend in efficacy compared to conventional Western medicine alone in improving clinical symptoms, joint function, and pain in patients with KOA, with comparable safety. The prescribing pattern aligns with the traditional Chinese medicine theory of"tonifying the kidney and activating blood", with the Achyranthes-Spatholobus pair being central. Further in-depth research is warranted. |
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