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| Research progress on the mechanism of traditional Chinese medicine in the prevention and treatment of diabetes mellitus complicated with coronary heart disease |
| Hits 1076 Download times 49 Received:November 16, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.02.15 |
| Key Words
traditional Chinese medicine;signaling pathway;diabetes mellitus;coronary heart disease;mechanism |
| Author Name | Affiliation | E-mail | | SU Yimeng | Department of Cardiovascular Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine of Henan Province, Zhengzhou 450000, China
Prevention and Control Center for Chronic Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | ZHU Mingjun | Department of Cardiovascular Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine of Henan Province, Zhengzhou 450000, China
Prevention and Control Center for Chronic Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | zhumingjun317@163.com | | WEI Jingjing | Department of Cardiovascular Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine of Henan Province, Zhengzhou 450000, China
Prevention and Control Center for Chronic Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | WU Wenjun | Department of Cardiovascular Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine of Henan Province, Zhengzhou 450000, China
Prevention and Control Center for Chronic Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | ZHAO Qifei | Department of Cardiovascular Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine of Henan Province, Zhengzhou 450000, China
Prevention and Control Center for Chronic Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | WANG Xinlu | Department of Cardiovascular Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine of Henan Province, Zhengzhou 450000, China
Prevention and Control Center for Chronic Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | CUI Ruyuan | Department of Cardiovascular Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine of Henan Province, Zhengzhou 450000, China
Prevention and Control Center for Chronic Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China | |
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| Abstract
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| Diabetes mellitus (DM) and coronary heart disease (CHD) are highly prevalent chronic metabolic and cardiovascular diseases globally. Their comorbidity has emerged as a major public health challenge in China. Investigations indicate that the incidence of DM-CHD comorbidity in China is rising annually, posing a significant threat to patient health due to its high morbidity and mortality rates. Current clinical treatments for DM combined with CHD primarily rely on pharmacological and surgical interventions, which suffer from limitations such as single therapeutic targets, significant side effects, and high complication rates. These issues substantially impact patients'quality of life and prognosis.In recent years, traditional Chinese medicine (TCM) has demonstrated unique advantages in the prevention and treatment of DM combined with CHD. Extensive clinical research confirms that TCM can significantly improve clinical symptoms and reduce diabetic complications by modulating multiple signaling pathways, with minimal adverse reactions. Based on this evidence, this review systematically summarizes the TCM-mediated regulation of signaling pathways relevant to DM-CHD comorbidity. It reveals that Chinese herbal medicine, Chinese medicine monomer, Chinese herbal formula, and Chinese patent medicine influence the occurrence and progression of DM combined with CHD by precisely modulating multiple signaling pathways. These mechanisms involve inhibiting inflammatory responses, apoptosis, disorders of glucose and lipid metabolism, oxidative stress, vascular endothelial dysfunction, and myocardial fibrosis.This review aims to identify candidate Chinese herbs and active components with well-defined pathway regulatory effects and elucidate the multi-target synergistic mechanisms of TCM formulas. The goal is to promote the optimization of precision integrative Chinese and Western medicine treatment strategies, thereby providing more robust scientific evidence and superior therapeutic solutions for the clinical management of DM combined with CHD. |
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