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| Advances in the study of traditional Chinese medicine regulating the Wnt/β-catenin signaling pathway for the prevention and treatment of gastric cancer |
| Hits 239 Download times 20 Received:December 08, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.02.18 |
| Key Words
Wnt/β-catenin;signal pathway;gastric cancer;traditional Chinese medicine;review |
| Author Name | Affiliation | E-mail | | KANG Li | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | MAO Chengdan | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | LIU Pengpeng | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | YUAN Xueling | Gansu University of Chinese Medicine, Lanzhou 730000, China | | | SHU Jin | The First Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730050, China | 1605786639@qq.com |
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| Abstract
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| Gastric cancer, as the fifth most common malignant tumor globally, presents an especially severe challenge in China. Traditional treatment approaches such as surgery and chemoradiotherapy have limitations, with the five-year survival rate for advanced patients remaining below 30%. Consequently, the pursuit of more effective and safer treatment strategies has become a critical issue urgently needing resolution in the field of oncology medicine. Recent studies have revealed that aberrant activation of the Wnt/β-catenin signaling pathway is directly associated with malignant behaviors in gastric cancer cells, including proliferation and metastasis. Traditional Chinese medicine (TCM) demonstrates unique advantages in anti-gastric cancer treatment. Through synergistic actions on multiple pathways, mechanisms, and signaling routes, it effectively prevents postoperative recurrence and metastasis, mitigates the adverse effects of chemoradiotherapy, and improves patients'quality of life, becoming a crucial step in the comprehensive treatment system for gastric cancer. Numerous research findings indicate that TCM active ingredients, such as terpenoids, polyphenols, flavonoids, alkaloids, polysaccharide complexes, and phenanthraquinones, alongside classic TCM formulas like Shenqi Yiliu Formula, Jiawei Xiaoxianxiong Decoction, Buzheng Huoxue Decoction, Sijunzi Decoction, and Moluodan, exhibit significant regulatory effects on the Wnt/β-catenin signaling pathway. They primarily influence the development and progression of gastric cancer by modulating gastric cancer cell autophagy, inhibiting apoptosis, affecting epithelial-mesenchymal transition, regulating drug resistance, and driving the cell cycle, thereby emerging as key targets in anti-gastric cancer research. This article comprehensively reviews and summarizes relevant research on TCM in combating gastric cancer over the past five years, focusing on the mechanisms by which TCM regulates the Wnt/β-catenin signaling pathway to treat gastric cancer. The aim is to offer new perspectives and reference for the clinical development of novel anti-gastric cancer drugs. |
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