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| Chinese medicine master WANG Xixing treating chemotherapy-related diarrhoea from the perspective of “drug toxicity”based on the theory of “zang-fu extea-ordinary connection” |
| Hits 22 Download times 0 Received:September 29, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.04.03 |
| Key Words
chemotherapy-associated diarrhea;zang-fu extea-ordinary connection;drug poisons;famous doctor experience |
| Author Name | Affiliation | E-mail | | LIU Yichan | Shanxi University of Chinese Medicine, Taiyuan 030024, China | | | WANG Haiyan | Shanxi Provincial Institute of Traditional Chinese Medicine, Taiyuan 030012, China | | | SHI Zhiyao | Shanxi University of Chinese Medicine, Taiyuan 030024, China | | | GAO Yu | Shanxi Provincial Institute of Traditional Chinese Medicine, Taiyuan 030012, China | | | WANG Xixing | Shanxi Provincial Institute of Traditional Chinese Medicine, Taiyuan 030012, China | wangxx315@163.com |
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| Abstract
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| Chemotherapy-induced diarrhea（CID） is a common adverse reaction to chemotherapy. Mild cases impair patients’ quality of life and disrupt treatment schedules，while severe cases may be life-threatening. Current Western medicine primarily relies on symptomatic management with limited efficacy. Expanding the traditional concept of zang-fu relationships in traditional Chinese medicine（TCM），this study innovatively analyzes CID through the lens of the “zang-fu extea-ordinary connection” theory（viscera interconnection beyond conventional pairings）. By correlating the cold/heat nature of chemotherapeutic agents，the pathological mechanisms are explored via four pathways：spleen-small intestine，kidney-triple energizer，liver-large intestine，and heart-gallbladder. Specifically，cold-natured chemotherapeutics initially impair spleen yang，leading to dysfunction of the small intestine in regulating fluids；in later stages，they damage kidney yang，obstructing triple energizer’s water metabolism. Heat-natured agents trigger liver fire hyperactivity（causing large intestine dysmotility） and heart fire excess（resulting in gallbladder heat descending to the large intestine）. Clinically，targeted therapies are proposed：strengthening spleen yang to regulate small intestine function，tonifying kidney yang to promote triple energizer’s qi transformation，clearing liver fire to restore large intestine motility，and purging heart fire to normalize gallbladder heat. Modified formulas such as Shengyang Zhixie Formula，Bushen Lishui Decoction，Gegen Qinlian Decoction，and Chaihu Qingdan Decoction are applied with marked efficacy. |
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