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| A study on the correlation between early renal injury and traditional Chinese medicine syndrome elements in asymptomatic lower extremity atherosclerosis based on cardiovascular-kidney-metabolic syndrome |
| Hits 21 Download times 0 Received:September 30, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.04.07 |
| Key Words
asymptomatic lower extremity atherosclerosis;early renal injury;cardiovascular-kidney-metabolic syndrome;TCM |
| Author Name | Affiliation | E-mail | | PU Yuling | Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | CHEN Xianchuan | Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | QIAN Fenghua | Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | JIANG Kai | Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | WANG Zhaozheng | Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | ZHANG Jiawei | Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | SHEN Rong | Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | rrrooonnnggg@126.com |
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| Abstract
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| [Objective] Based on the cardiovascular-kidney-metabolic（CKM） framework，this study aimed to explore the correlation between early renal injury and traditional Chinese medicine（TCM） syndrome elements in patients with asymptomatic lower extremity arterial atherosclerosis（LEAD）. [Methods] A retrospective analysis was conducted on 216 asymptomatic LEAD patients，who were categorized into a normal microalbuminuria（MAU） group（MAU<30 mg/L，140 cases） and an abnormal MAU group（MAU≥30 mg/L，76 cases）. The distribution of TCM syndrome elements was compared between groups. Spearman correlation and binary logistic regression were used to examine associations between syndrome elements and renal function indicators. [Results] The abnormal MAU group had significantly higher age，proportion of hypertension history，Crouse score，serum creatinine，and cystatin C，but lower ankle-brachial index（ABI） and estimated glomerular filtration rate（eGFR），P<0.05. The predominant TCM syndrome elements were phlegm-turbidity（50.0%），qi deficiency（47.7%），and blood stasis（43.5%）. The proportion of phlegm-turbidity was significantly higher in the abnormal MAU group（61.8%） than in the normal group（43.6%，P<0.05）. Logistic regression identified history of hypertension（OR=2.106），ABI（OR=0.153），and phlegm-turbidity（OR=2.043） as independent influencing factors for abnormal MAU（P<0.05）. [Conclusion] Early renal injury in asymptomatic LEAD patients results from the synergistic effects of hypertension，vascular lesions，and metabolic disorders. The high prevalence of phlegm-turbidity syndrome element and its significant association with MAU abnormality suggest its core role in the “metabolic-vascular-renal” injury axis，providing a new perspective for integrated Chinese and Western medicine interventions. |
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