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| Study on the quality standard of traditional Chinese medicine fermented preparation: Chenxiangqu |
| Hits 4 Download times 0 Received:December 24, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2026.04.12 |
| Key Words
Chenxiangqu;quality standard;TCL identification;content determination;test items;network pharmacology |
| Author Name | Affiliation | E-mail | | ZOU Lin | Institute of Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SONG Luying | Institute of Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YE Yalin | Institute of Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Xiangdong | Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | YANG Jing | Institute of Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | DOU Zhiying | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, National Administration of Traditional Chinese Medicine Heritage Base for Traditional Chinese Medicine Processing Technology(Tianjin), National Inheritance Studio of Veteran Pharmacists, Tianjin 301617, China | | | WANG Yuefei | Institute of Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | CHAI Xin | Institute of Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | chaix0622@tjutcm.edu.cn |
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| Abstract
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| [Objective] This study aims to establish a quality standard for Chenxiangqu and to predict components for TLC identification and content determination by integrating network pharmacology，thereby providing a scientific basis for its standardized application. [Methods] A “Component-Target-Pathway” network of Chenxiangqu was constructed using network pharmacology. Eight batches of Chenxiangqu were analyzed，with nodakenin selected as the main active ingredient for qualitative identification by thin-layer chromatography（TLC）. The content of puerarin was determined by high-performance liquid chromatography（HPLC）. In addition，routine test items including moisture and total ash were carried out according to the methods specified in the Chinese Pharmacopoeia. [Results] Network analysis indicated that puerarin and nodakenin may serve as potential quality markers for Chenxiangqu. TLC results revealed clear blue fluorescent spots at the positions corresponding to the nodakenin reference，with good separation. The study established that the moisture content should not be more than 11.0% and the total ash not more than 4.0%，along with setting the content standard requiring that the puerarin content in Chenxiangqu shall not be less than 0.2%. [Conclusion] By systematically characterizing the quality attributes of Chenxiangqu combined with network pharmacology，a comprehensive quality evaluation system was developed incorporating physicochemical tests，TLC identification and content determination，thus providing a reliable approach for quality control of Chenxiangqu. |
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