|
| Evaluation of animals models with perimenopausal insomnia based on clinical disease and syndrome characteristics of traditional Chinese medicine and Western medicine |
| Hits 26 Download times 0 Received:September 29, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2026.04.16 |
| Key Words
perimenopausal insomnia;traditional Chinese and Western medicine;animal model;consistency;comorbidity |
| Author Name | Affiliation | E-mail | | SUN Xiaohui | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | TANG Ling | The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | tangling73@126.com | | YU Mingyue | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHAO Jingjing | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | HUANG Wenxin | Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | |
|
| Abstract
|
| Insomnia is the most common sleep disorder in the period of perimenopause，and it is also an independent risk factor for accelerating the process of chronic co-morbidities in the elderly，such as neurodegenerative diseases and cardiovascular and metabolic diseases. We analyzed the characteristics and deficiencies of the existing animal models of Perimenopausal insomnia，with the aim of proposing suggestions and perspectives for the combined model of PMI. Animal models of PMI were systematically analyzed based on the diagnostic criteria of Chinese and Western medicine and the model evaluation system，in terms of modeling method（unifactorial/multifactorial induction），mechanism of action，evaluation indexes，model validity，and clinical compatibility. Existing models can be categorized into two types of modeling systems：unifactorial（drug，surgery，stress induction） and multifactorial（drug+stress，surgery+stress，surgery+drug）. Among them，the deoxyvinylcyclohexene（4-VCD） combined with p-chlorophenylalanine（PCPA）-induced model showed the best performance in terms of clinical match between Chinese and Western medicine，which was consistent with the characteristics of the disease in Western medicine，and also reflected the characteristics of Chinese medicine. At present，there are fewer studies on animal models of composite diseases，and most of them are disease models，and there is a lack of research on disease-combination models. In the future，efforts should be made to construct a composite model that meets both the disease characteristics of Western medicine and the symptoms of Chinese medicine，which is of great scientific value to deepen the research on the pathogenesis of PMI and the evaluation of pharmacological efficacy. |
|
