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| Research progress on traditional Chinese medicines regulating endoplasmic reticulum stress in the intervention of colorectal cancer |
| Hits 19 Download times 1 Received:January 18, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.05.15 |
| Key Words
colorectal cancer;endoplasmic reticulum stress;mechanism;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LIANG Lei | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Le | West China Hospital Sichuan University Jintang Hospital-Jintang First People's Hospital, Chengdu 610400, China | | | PENG Xin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Shihong | Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China | | | LIANG Hairong | North Sichuan Medical College, Nanchong 637000, China | | | ZHANG Yutian | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Tianlin | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LI Zhenyu | West China Hospital Sichuan University Jintang Hospital-Jintang First People's Hospital, Chengdu 610400, China | 443123903@qq.com | | WANG Hong | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | ctwanghong@sina.com |
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| Abstract
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| Colorectal cancer（CRC） is one of the most prevalent malignant tumors in the digestive system，with consistently high incidence and mortality rates，making it a significant global public health concern. The pathogenesis of CRC is highly complex，and its early symptoms are often nonspecific，which leads to delayed diagnosis and difficult treatment. Moreover，the overall prognosis remains unfavorable. Current therapeutic approaches，including surgical resection，radiotherapy，and chemotherapy，are associated with various limitations. Therefore，the development of safe，effective，and low-toxicity therapeutic strategies has become an urgent priority in clinical oncology. Accumulating evidence indicates that endoplasmic reticulum stress（ERS） plays a crucial role in the initiation and progression of CRC，as well as in tumor cell proliferation，invasion，metastasis，and drug resistance. Targeted modulation of ERS signaling pathways may offer a promising novel approach for the intervention of CRC. Multiple studies have confirmed that the active components of traditional Chinese medicine，owing to their advantages of multi-target，multi-pathway and multi-level actions，are widely utilized in the prevention and treatment of CRC，making them a prominent focus of recent research. Active ingredients of Chinese medicines，including terpenoids，phenylpropanoids，polyphenols，quinones，steroids and alkaloids，have been demonstrated to exert anti-CRC effects by modulating ERS-related signaling pathways. These mechanisms involve inducing tumor cell apoptosis and autophagy，arresting cancer cell cycles，regulating epithelial-mesenchymal transition，enhancing chemosensitivity，and inhibiting tumor cell proliferation and migration. This article aims to systematically review the mechanisms and therapeutic potential of TCM-mediated ERS regulation in CRC management，synthesizing domestic and international research over the past decade. It also addresses current research limitations，aiming to provide insights and references for the development of future CRC prevention strategies and novel therapeutic agents. |
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