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| Effects of union of Buyang Huanwu Decoction and meglumine adenosine cyclophosphate on cardiac function and serum sST2 and NT-proBNP in patients with qi deficiency and blood stasis type coronary heart disease and heart failure |
| Hits 243 Download times 56 Received:January 20, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.06.06 |
| Key Words
soluble growth stimulation expressed gene 2;N-terminal pro-B-type natriuretic peptide;qi deficiency and blood stasis syndrome;coronary heart disease and heart failure;cardiac function |
| Author Name | Affiliation | E-mail | | LI Duo | Department of Integrated Traditional Chinese and Western Medicine, Handan First Hospital, Handan 056000, China | | | LI Haiyan | Department of Traditional Chinese Medicine Classics, Handan Hospital of Integrated Traditional Chinese and Western Medicine, Handan 056000, China | | | WANG Ran | Department of Integrated Traditional Chinese and Western Medicine, Handan First Hospital, Handan 056000, China | | | WANG Yumei | Department of Integrated Traditional Chinese and Western Medicine, Handan First Hospital, Handan 056000, China | 110557535@qq.com |
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| Abstract
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| [Objective] Coronary heart disease（CHD）with heart failure is one of the main causes of death from cardiovascular diseases，and qi deficiency with blood stasis syndrome is a common traditional Chinese medicine（TCM）syndrome type in such patients. To explore the effects of Buyang Huanwu Decoction combined with meglumine adenosine cyclophosphate on cardiac function and the levels of serum soluble growth stimulation expressed gene 2（sST2）and N-terminal pro-B-type natriuretic peptide（NT-proBNP）in these patients. [Methods] A prospective randomized controlled trial design was adopted. Ninety patients with qi deficiency and blood stasis type CHD and heart failure admitted were included as the research subjects. The patients were randomly assigned into three groups A，B，and C according to the random number table，each had 30 cases. In addition to basic treatment，group A was given intravenous injection of meglumine adenosine cyclophosphate，group B was given Buyang Huanwu Decoction，and group C was given intravenous injection of meglumine adenosine cyclophosphate+Buyang Huanwu Decoction. The TCM syndromes，laboratory indicators， cardiac function indicators，serum sST2，and NT- proBNP were observed in three groups before treatment（T0）and after 4 weeks of treatment（T1），and the clinical efficacy and adverse reactions were comprehensively evaluated. [Results] At T1，the scores of traditional Chinese medicine syndrome，LVEDD，LVESD，serum HCT，FIB，sST2，and NT-proBNP in the three groups were prominently lower than those in the same group at T0（P<0.05），and with group C being prominently lower than groups A and B（P<0.05）. The LVEF of the three groups were prominently increased，and with C group being prominently higher than the A and B groups （P<0.05）. The total effective rate of group C（93.33%）was prominently higher than that of group A（70.00%）and group B（66.67%）， P<0.05. There was no statistically significant difference in the overall incidence of adverse reactions among the three groups（P>0.05）. [Conclusion] The union of Buyang Huanwu Decoction and meglumine adenosine cyclophosphate can improve the cardiac function of patients with qi deficiency and blood stasis type CHD and heart failure，and reduce serum sST2 and NT-proBNP. |
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