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| Exploration of plasma lipid biomarkers associated with heart failure risk in individuals with phlegm-dampness constitution based on the theory of “similar diseases and syndromes of damp-turbidity-phlegm-rheum” |
| Hits 63 Download times 34 Received:April 04, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.07.03 |
| Key Words
similar diseases and syndromes of damp-turbidity-phlegm-rheum;phlegm-dampness constitution;heart failure;mendelian randomization |
| Author Name | Affiliation | E-mail | | GUO Junchi | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HUANG Ming | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Mingyan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Qilong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XIONG Ke | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | KAN Xiangling | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Qiang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LU Meijuan | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | lmj830127@163.com |
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| Abstract
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| [Objective] Heart failure（HF）is the terminal stage of cardiovascular diseases，with high morbidity and mortality. The theory of“similar diseases and syndromes of damp-turbidity-phlegm-rheum”proposed by renowned master of traditional Chinese medicine（TCM）ZHANG Boli，provides valuable insights into the pathogenesis and treatment of HF. According to this theory，there is a potential correlation between HF risk and phlegm-dampness constitution. This study aims to explore plasma lipid biomarkers associated with heart failure risk in individuals with phlegm-dampness constitution and reveal their potential metabolic mechanisms using modern omics technologies. [Methods] This study is based on genome-wide association study（GWAS）data from international public databases. Mendelian randomization（MR）analysis was employed，combined with lipidomics data，to investigate the causal relationship between phlegm-dampness constitution and HF. Two-step MR analysis was further conducted to calculate the mediating effects of plasma lipid biomarkers between phlegm-dampness constitution and HF risk. [Results] The results show that phlegm-dampness constitution significantly increases the risk of HF（OR=1.205，P<0.001）. Furthermore，56 plasma lipid metabolites were significantly associated with HF risk，of which 30 lipid biomarkers play a mediating role between phlegm-dampness constitution and HF risk. [Conclusion] Within the framework of the“similar diseases and syndromes of damp-turbidity-phlegm-rheum”theory，this study applied genetic causal inference to evaluate the association between metabolic traits related to phlegm-dampness constitution and heart failure risk，and identified plasma lipid biomarkers with potential mediating roles. These results provide methodological support for the quantitative study of constitution-related cardiovascular risk and offer data reference for constitution-based cardiovascular risk assessment research. |
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