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| Effectiveness and safety of different dosage forms of Xuefu Zhuyu Decoction in the treatment of heart system diseases based on network Meta-analysis |
| Hits 81 Download times 34 Received:April 12, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.07.07 |
| Key Words
heart system diseases;network Meta-analysis;Chinese patent medicine;dosage form;Xuefu Zhuyu |
| Author Name | Affiliation | E-mail | | YU Zixuan | Hunan University of Chinese Medicine, Changsha 410208, China | | | KONG Beibei | Hunan University of Chinese Medicine, Changsha 410208, China | | | CHEN Xing | Hunan University of Chinese Medicine, Changsha 410208, China | | | WU Zizheng | Hunan University of Chinese Medicine, Changsha 410208, China | | | MAO Yan | Hunan University of Chinese Medicine, Changsha 410208, China | 2022698533@qq.com |
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| Abstract
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| [Objective] Frequency network Meta-analysis method was used to conduct a systematic evaluation of the effectiveness and safety of different dosage forms of Xuefu Zhuyu Decoction in the treatment of Heart system diseases. [Methods] Use computers to search PubMed，Web of Science，Embase，Cochrane Library，China National Knowledge Infrastructure（CNKI），VIP Chinese Science and Technology Journal Database（VIP），Wanfang Database，Chinese Biomedical Literature Database（CBM），and multiple domestic and foreign mainstream clinical trials.The time limit for registering relevant randomized controlled clinical trials（RCTs）on the website is from the establishment of the database to December 31st，2024. Different researchers independently conducted multi-level screening of the literature，conducted quality control according to the contents of the Cochrane Systematic Review Manual，and used the Network package of Stata16 to perform network Meta analysis. [Results] A total of 53 RCT studies were included，involving 4 817 patients with cardiovascular diseases such as coronary heart disease，heart failure，and pulmonary heart disease. The intervention measures in the experimental group were Xuefu Zhuyu Tablets，Xuefu Zhuyu Oral Liquid，Xuefu Zhuyu Granules，Xuefu Zhuyu Pills，Xuefu Zhuyu Capsules，and Xuefu Zhuyu Decoction combined with conventional western medicine. The control group was treated with conventional western medicine. Network Meta-analysis results suggest that：1）In terms of clinical effectiveness，decoction has the best effect. 2）Granules have the best effect in reducing C-reactive protein（CRP），brain natriuretic peptide（BNP）levels and the frequency of angina attacks. 3）Capsules The agent has the best effect in reducing the duration of angina pectoris and the level of left ventricular ejection fraction（LVEF）.4）The adverse reactions and the number of long-term cardiovascular events of the Xuefu Zhuyu Decoction preparation are lower than those of conventional Western medicine，which means it is mach more safer. [Conclusion] In the treatment of cardiovascular diseases，the efficacy of conventional Western medicine combined with Xuefu Zhuyu Decoction is better than the former.Among them，in order to obtain the best clinical effect，decoction should be recommended first.In addition，granules have the best effect in reducing CRP，BNP and the frequency of angina pectoris attacks，while capsules are more effective in reducing the duration of angina pectoris and improving LVEF. Physicians should flexibly choose dosage forms with better efficacy based on the patient’s clinical indications，in order to improve the efficacy while reducing adverse reactions and allowing patients to obtain long-term benefits. |
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