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| Overview of the study on oxidative stress and vascular endothelial function mechanism of traditional Chinese medicine in the treatment of essential hypotension |
| Hits 295 Download times 110 Received:May 13, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.10.17 |
| Key Words
essential hypotension;oxidative stress;vascular endothelial function;efficacy of traditional Chinese medicine;both qi and blood deficiency;syndrome differentiation and classification;treatment mechanism |
| Author Name | Affiliation | E-mail | | MEI Yuting | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Xuan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | FAN Huimin | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHOU Mengxue | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Xianliang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | xlwang1981@126.com | | MAO Jingyuan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | |
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| Abstract
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| Essential hypotension is a chronic circulatory system disease characterized by persistent hypotension(systolic blood pressure < 90 mmHg and/or diastolic blood pressure < 60 mmHg, 1 mmHg≈0.133 kPa). The patient population is particularly high in the frail young people at home and abroad, which can increase the risk of fainting, falling and cardiocerebral ischemia. Modern medical treatment has limitations such as many adverse reactions and single efficacy, while traditional Chinese medicine has shown unique advantages through multiple targets to regulate oxidative stress and vascular endothelial dysfunction. This paper systematically sorts out the etiology, pathogenesis and syndrome laws of essential hypotension, and combines modern medical mechanisms to explore the targets of traditional Chinese medicine to improve blood pressure homeostasis by regulating oxidative stress and vascular endothelial function. Combined with modern pharmacological research, we analyze the molecular pathways of the effects of Chinese medicine compound and acupuncture, and summarize the evidence-based basis for improving blood pressure homeostasis by regulating key targets such as superoxide dismutase(SOD) and nitric oxide(NO)/endothelin-1(ET-1) balance, in order to provide theoretical support for the development of low-toxic and efficient traditional Chinese medicine treatment plans and individualized precision medicine strategies. |
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