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| Research progress on the neuroprotective effects of terpenoid compounds from traditional Chinese medicine in cerebral ischemia-reperfusion injury |
| Hits 327 Download times 108 Received:April 30, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.10.18 |
| Key Words
cerebral ischemia-reperfusion injury;traditional Chinese medicine;terpenoid compounds;neuroprotection;mechanisms of action |
| Author Name | Affiliation | E-mail | | NI Ke | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Lin | College of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | 158005329@qq.com |
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| Abstract
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| Cerebral ischemia-reperfusion injury(CIRI) is a severe global public health issue, with its high morbidity and mortality rates drawing widespread attention. Despite some progress in modern medicine for CIRI treatment, efficacy is often limited due to the use of single treatment methods and the limitations of drug application. In recent years, traditional Chinese medicine(TCM) has demonstrated unique advantages in the treatment of CIRI, especially terpenoid compounds, which, due to their multi-target and multi-pathway properties, have become a research hotspot in the field of neuroprotection. Terpenoid compounds not only possess antioxidant, anti-inflammatory, and anti-apoptotic functions but also improve the permeability of the blood-brain barrier, promote neurovascular remodeling, and stimulate angiogenesis, thus effectively alleviating brain tissue damage caused by CIRI. This article, in combination with recent domestic and international research findings, comprehensively discusses the neuroprotective effects of TCM terpenoid compounds in CIRI through the regulation of key molecular signaling pathways, explaining their mechanisms in antioxidant stress, inflammation inhibition, and the reduction of brain tissue cell damage. Through this review, we aim to provide a theoretical basis for the clinical application of TCM terpenoid compounds and point out new directions for the future development of neuroprotective drugs. |
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