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| Research progress in traditional Chinese medicine for obesity treatment based on the sirt1 signaling pathway |
| Hits 292 Download times 122 Received:April 28, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.10.19 |
| Key Words
obesity;SIRT1 signaling pathway;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LI Juan | Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | SUN Yi | The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China | | | SUN Quanhao | Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | LI Jiarui | Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | DU Likun | The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China | dulikun@hljucm.edu.cn |
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| Abstract
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| Obesity is a risk factor for various metabolic diseases, and its global prevalence has been rising steadily, emerging as a major public health challenge worldwide. Studies demonstrate that Sirtuins 1(SIRT1) modulates obesity-related pathophysiological mechanisms primarily through targeting downstream signaling molecules including AMP-activated protein kinase(AMPK), Peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α), Peroxisome proliferator-activated receptor gamma(PPARγ), Nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB), Forkhead box O-class proteins(FoxO), and Phosphatidylinositol 3-kinase(PI3K). These regulatory effects encompass white adipose browning, inflammatory responses, oxidative stress balance, insulin resistance(IR) amelioration, glucose and lipid metabolism dysregulation, and gut microbiota homeostasis, collectively contributing to weight reduction and metabolic regulation. Numerous studies have demonstrated that traditional Chinese medicine(TCM) exhibits anti-obesity effects based on SIRT1 pathway activation, characterized by multi-target synergism, pathway diversity, and favorable safety profiles. Nevertheless, systematic reviews elucidating these mechanisms remain scarce. Therefore, based on recent domestic and foreign research, this article aims to gain a deeper understanding of the mechanism of action of the SIRT1 pathway in obesity, and summarize the current research status of using TCM monomers, formulas, and acupuncture to treat obesity through the SIRT1 pathway. The goal is to provide theoretical basis and new ideas for the clinical treatment of obesity and the development of targeted drugs. |
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