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| Research progress on NETs mediated targeted treatment of inflammatory bowel disease with traditional Chinese medicine and natural products |
| Hits 380 Download times 145 Received:April 28, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.10.20 |
| Key Words
inflammatory bowel disease;traditional Chinese medicine;natural products;neutrophil extracellular trapping net;inflammation |
| Author Name | Affiliation | E-mail | | LI Siqi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YU Li | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAN Gouling | Tianjin Medical University, Tianjin 300140, China | | | BAO Cuiping | Tianjin Union Medical Center, Tianjin 300121, China | | | LIU Xuehuan | Tianjin Union Medical Center, Tianjin 300121, China | | | GAO Xiao | Tianjin Fourth Central Hospital, Tianjin 300241, China | | | LIU Jun | Tianjin Fourth Central Hospital, Tianjin 300241, China | cjr.liujun@vip.163.com |
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| Abstract
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| Inflammatory bowel disease(IBD) is an autoimmune condition encompassing ulcerative colitis and Crohn's disease. Neutrophils play a pivotal role in innate immunity by migrating to inflammatory sites, where they phagocytize pathogens, induce oxidative stress through the release of reactive oxygen species(ROS), and form neutrophil extracellular traps(NETs), collectively amplifying the inflammatory response. NETs are DNA-based networks rich in bioactive proteins, and their excessive release exacerbates inflammation, disrupts the intestinal barrier, damages vascular endothelial cells, and increases the risk of thrombosis in IBD. Although the etiology of IBD remains unclear, dysregulated NETs formation is closely linked to the progression of intestinal inflammation. Given the limited efficacy or significant side effects of conventional IBD medications, traditional Chinese medicine and natural products offer promising potential as alternatives to standard treatments. This review explores the impact of NETs on IBD and summarizes preclinical studies on translation of traditional Chinese medicine and natural products targeting NETs for treating inflammatory diseases, including IBD. By elucidating the underlying mechanisms, we aim to support the future clinical translation of traditional Chinese medicine and natural products. |
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