|
| Three kinds of Chinese patent medicine for immunodulation in treating psoriasis vulgaris：A systematic review and network Meta-analysis |
| Hits 481 Download times 159 Received:June 30, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2025.11.09 |
| Key Words
psoriasis vulgaris;compound glycyrrhizin;total glucosides of paeony;tripterygium glycosides;systematic review;network Meta-analysis |
| Author Name | Affiliation | E-mail | | DING Jiuli | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Yan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | GUO Xiaojing | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | KA Yuxiu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Baohe | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | wbh3423@sina.com |
|
| Abstract
|
| [Objective] Compound glycyrrhizin（CG），total glucosides of paeony（TGP），and tripterygium glycosides（TG） all possess immunomodulatory properties. However，their therapeutic efficacy in the treatment of psoriasis vulgaris（PV） may differ，creating uncertainty in clinical decision-making. This study aims to evaluate the efficacy and safety of CG，TGP and TG，each in combination with regular treatment（RT），in the management of PV，in order to provide evidence-based guidance for clinical practice. [Methods] This study included literature from eight databases up to August 2024，selecting randomized controlled trials（RCTs） that focused on PV. The control group received RT，while the treatment group received RT combined with CG，TGP or TG. A Bayesian network Meta-analysis（NMA） was performed to assess the psoriasis area and severity index（PASI） 90 response rate，PASI score，interleukin（IL）-17 levels，and other outcomes. The efficacy ranking was evaluated using the surface under the cumulative ranking（SUCRA）. [Results] A total of 61 studies involving 5 660 patients were included to assess the efficacy of CG，TGP and TG in combination with RT. Compared with RT alone，all three interventions（CG，TGP，and TG） significantly improved the PASI90 response rate，reduced PASI scores，and decreased IL-17 levels. According to SUCRA ranking results，CG showed the best performance in terms of PASI90 response rate and IL-17 reduction，while TG demonstrated the most significant improvement in PASI scores. The incidence of adverse events in the control group was higher than in the treatment groups，with a statistically significant difference，indicating good safety profiles for the treatment regimens. [Conclusion] CG，TGP and TG each demonstrated significant therapeutic benefits for PV when combined with RT. CG may be the most effective in enhancing the PASI90 response rate and reducing IL-17 levels，while TG appeared to be more prominent in improving PASI scores. |
|
|
|
|
|
|
|
