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| Research progress of molecular mechanism of intervening in ventricular remodeling after myocardial infarction by blood-activating and blood-stasis-eliminating traditional Chinese medicine |
| Hits 320 Download times 115 Received:June 30, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.11.16 |
| Key Words
myocardial infarction;ventricular remodeling;activating blood circulation and removing blood stasis;molecular mechanism |
| Author Name | Affiliation | E-mail | | LUO Jiyang | Hubei University of Traditional Chinese Medicine, Wuhan 430061, China | | | LIU Fuli | Hubei University of Traditional Chinese Medicine, Wuhan 430061, China | | | DU Ze | Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Hubei Hospital of Traditional Chinese Medicine, Hubei Academy of Traditional Chinese Medicine, Wuhan 430061, China | | | LIU Xiaqing | Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Hubei Hospital of Traditional Chinese Medicine, Hubei Academy of Traditional Chinese Medicine, Wuhan 430061, China | | | WANG Qingxuan | Hubei University of Traditional Chinese Medicine, Wuhan 430061, China | | | JIANG Yong | Hubei University of Traditional Chinese Medicine, Wuhan 430061, China | | | DENG Boyi | Hubei University of Traditional Chinese Medicine, Wuhan 430061, China | | | LIU Liang | Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Hubei Hospital of Traditional Chinese Medicine, Hubei Academy of Traditional Chinese Medicine, Wuhan 430061, China | 759035376@qq.com |
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| Abstract
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| Ventricular remodeling after myocardial infarction is an important factor leading to heart failure and cardiovascular events. As the representative of traditional Chinese medicine，drugs for activating blood circulation and removing blood stasis show unique advantages in improving cardiovascular diseases. A variety of traditional Chinese medicine compounds and monomers with the effect of promoting blood circulation and removing blood stasis can reduce myocardial cell injury and promote the recovery of ventricular function by regulating programmed cell death，inhibiting inflammatory reaction，oxidative stress，reducing myocardial fibrosis and promoting angiogenesis，reducing autophagy and pyrosis of myocardial cells. Through the in-depth study on the molecular mechanism of activating blood circulation and removing blood stasis in the intervention of ventricular remodeling after myocardial infarction，it was found that it can target multiple molecular pathways，showing high safety and effectiveness，providing a new idea for the treatment of ventricular remodeling after myocardial infarction. |
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