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| Research progress of mitochondrial quality control against osteoporosis and herbal medicine treatment |
| Hits 249 Download times 99 Received:August 10, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2025.11.17 |
| Key Words
osteoporosis;mitochondrial quality control;traditional Chinese medicine;review |
| Author Name | Affiliation | E-mail | | CAO Dongdong | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | | | CHEN Jixin | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | | | YU Weijie | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | | | MENG Tao | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | | | ZHANG Xiaoyu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | | | WANG Junlong | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | | | LI Jiayu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | | | LIU Aifeng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture, Tianjin 300381, China | draifeng@163.com |
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| Abstract
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| Osteoporosis（OP） is characterized by decreased bone mass and destruction of bone microarchitecture，leading to an increased risk of fracture. Traditional Western medical treatments has limitations in terms of long-term use of side effects and maintenance of dynamic balance of bone metabolism. With the advantage of “multi-targeting and overall regulation”，Chinese medicine has gradually become a new direction for OP prevention and treatment. Recent studies have found that the mitochondrial quality control（MQC） mechanism（including mitochondrial biogenesis，kinetic homeostasis，oxidative stress regulation and autophagy） plays a central role in bone metabolism homeostasis，and its dysfunction is closely related to the occurrence of OP. However，existing studies have mostly focused on the validation of single pathways or targets，and the overall knowledge of the systemic regulatory network of MQC is still insufficient. This review systematically synthesizes research progress on Chinese medicine in preventing and treating OP through the regulation of MQC. It delves into the mechanisms by which Chinese medicine monomers and compounds intervene in mitochondrial dynamics，mitophagy activation，and antioxidant defense. The aim is to provide a theoretical reference for establishing the “TCM-MQC-Bone metabolism” research paradigm and to offer a theoretical basis for developing targeted therapeutic strategies based on the remodeling of mitochondrial homeostasis. |
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