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| Impacts of Chaihu Shugan Powder combined with mosapride citrate on clinical symptoms and intestinal flora abundance in patients with diabetic gastroparesis |
| Hits 593 Download times 221 Received:March 26, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.07.05 |
| Key Words
Chaihu Shugan Powder;mosapride;diabetic gastroparesis;clinical efficacy;gut microbiota abundance |
| Author Name | Affiliation | | SU Chuangze | Shanxi Traditional Chinese Medicine Hospital, Taiyuan 030012, China | | SHAN Chongwu | Shanxi Traditional Chinese Medicine Hospital, Taiyuan 030012, China | | NIU Yanyan | Shanxi Traditional Chinese Medicine Hospital, Taiyuan 030012, China | | JIN Guichun | Shanxi Traditional Chinese Medicine Hospital, Taiyuan 030012, China |
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| Abstract
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| [Objective] To explore the impacts of Chaihu Shugan Powder combined with mosapride citrate（MC） on clinical symptoms and intestinal flora abundance in patients with diabetic gastroparesis（DGP）. [Methods] From January 2022 to December 2023，the 120 DGP patients who visited hospital were separated into a Western medicine group and a combined group stochastically，with 60 patients in each group. The Western medicine group received MC treatment，while the combined group received Chaihu Shugan Powder combined with MC treatment. The efficacy，TCM syndrome scores，gastric emptying rate，gastrointestinal hormones，blood glucose levels，inflammatory factors，and abundance of gut microbiota in both groups were observed after treatment. [Results] The total effective rate of the combined group after treatment was 95.00%，which was obviously higher than the Western medicine group’s 80.00%（P＜0.05）. After treatment，the scores of postprandial fullness，acid reflux，nausea and vomiting，and abdominal pain in both groups were prominently reduced compared to before treatment，and the combined group was prominently lower than the Western medicine group（P＜0.05）. After treatment，the gastric emptying rate and IL-10 level in both groups obviously increased compared to before treatment，and the combined group was obviously higher than the Western medicine group（P＜0.05）. The levels of interleukin-6（IL-6），tumor necrosis factor-α（TNF-α），motilin（MTL），gastrin（GAS），fasting blood glucose，and 2-hour postprandial blood glucose in both groups obviously decreased，while the combined group was prominently lower than the Western medicine group（P＜0.05）. After treatment，the abundances of Firmicutes，Actinobacteria，Verrucomycota and Proteobacteria in both groups decreased prominently compared to before treatment，and the combined group was obviously lower than the Western medicine group（P＜0.05）. [Conclusion] The combination of Chaihu Shugan Powder and MC has a prominent effect on DGP patients，which can alleviate clinical symptoms，improve clinical efficacy，promote gastric emptying rate，improve intestinal hormones，gut microbiota abundance，and blood glucose levels，and reduce inflammatory reactions. |
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