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| Research progress on related signaling pathways of traditional Chinese medicine in preventing and treating cardiac dysfunction in sepsis |
| Hits 498 Download times 315 Received:February 20, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.08.17 |
| Key Words
sepsis;cardiac dysfunction;signaling pathway;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | XU Tongjia | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LEI Jing | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Xintong | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHU Yan | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | KONG Dexin | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | kongdexin@tmu.edu.cn | | FENG Yuxin | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | fengyn2016@163.com |
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| Abstract
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| Sepsis is a systemic inflammatory response caused by the invasion of pathogenic organisms such as bacteria into the body，which in turn induces septic shock and multi-organ dysfunction. Cardiac dysfunction is the leading cause of death in patients with sepsis，with a mortality rate of more than 70%. The use of traditional Chinese medicine in the treatment of sepsis has the characteristics of multiple targets，multiple pathways，and multiple mechanisms，which can alleviate cardiac dysfunction caused by sepsis by inhibiting inflammatory responses，regulating autophagy，and anti-apoptosis，but its related molecular mechanisms still need to be further explored. This review systematically sorts out the relevant signaling pathways involved in the treatment of cardiac dysfunction caused by sepsis，aiming to provide scientific basis and reference for future research and clinical treatment. |
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