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| Construction and application of animal models for lumbar disc herniation based on clinical characteristics in traditional Chinese and Western medicine |
| Hits 422 Download times 210 Received:February 11, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.08.18 |
| Key Words
lumbar disc herniation;clinical characteristics;traditional Chinese and Western medicine;animal models |
| Author Name | Affiliation | E-mail | | SHAN Kaixin | School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | LIU Fuyu | School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | TANG Yinbo | School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | FENG Yonggang | School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China | | | MIAO Mingsan | School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Genuine Medicine in Henan Province, Zhengzhou 450046, China | | | FANG Xiaoyan | School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Genuine Medicine in Henan Province, Zhengzhou 450046, China | fxylele@yeah.net |
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| Abstract
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| To evaluate the consistency between existing animal models of lumbar disc herniation（LDH） and clinical manifestations in both traditional Chinese and Western medicine. The existing LDH animal models were compared with clinical symptoms，imaging manifestations and traditional Chinese medicine syndrome differentiation，and the limitations of the existing models were analyzed. The nucleus pulposus transplantation model showed relatively high clinical consistency among existing LDH animal models. Current models fail to adequately consider the impact of climate factors on LDH progression or incorporate traditional Chinese medicine syndrome differentiation patterns. Future LDH animal model studies should emphasize traditional Chinese medicine syndrome classification characteristics by establishing diversified modeling approaches. Evaluation metrics should be improved by incorporating climate factors and traditional Chinese medicine syndrome differentiation indicators. |
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