|
| Research progress on anti-tumor effects of Polyphyllin |
| Hits 481 Download times 498 Received:February 20, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2025.08.19 |
| Key Words
Polyphyllin;chemistry;anti-tumor;toxicity and safety evaluation;research progress |
| Author Name | Affiliation | E-mail | | HAN Di | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Center for Drug Safety Evaluation and Research, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Chan | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Center for Drug Safety Evaluation and Research, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHOU Kun | Center for Drug Safety Evaluation and Research, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHU Na | Center for Drug Safety Evaluation and Research, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | tzzn116@163.com | | LIU Tianjun | Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | liutianjun926@163.com |
|
| Abstract
|
| Malignant tumors pose a significant threat to human health. Researchers have been extensively investigating the anti-tumor effects and underlying mechanisms of traditional Chinese medicine. Current studies demonstrate that Polyphyllin exhibits potent anti-tumor activities through multiple pathways，including inducing tumor cell apoptosis，regulating cell cycle，triggering protective autophagy in tumor cells，inhibiting tumor cell invasion and metastasis，reversing drug resistance，and producing synergistic anti-tumor effects. This review comprehensively summarizes the anti-tumor mechanisms of Polyphyllin reported in the past decade based on literature from PubMed，Web of Science，and CNKI databases，while also evaluating its toxicity and safety profiles. The findings may provide valuable theoretical references for further development of Polyphyllin as a multi-target anti-tumor agent and its clinical applications in cancer treatment. |
|
|
|
|
|
|
|
