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| The clinical efficacy of modified Danggui Niantong Decoction combined with calcium dobesilate tablets in treating diabetes peripheral neuropathy |
| Hits 538 Download times 208 Received:February 18, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2025.08.05 |
| Key Words
modified Danggui Niantong Decoction;calcium dobesilate tablet;diabetes peripheral neuropathy;clinical efficacy;inflammatory response |
| Author Name | Affiliation | | LIU Jindong | Department of Traditional Chinese Medicine, Tangshan Third Hospital, Tangshan 063000, China | | LIU Fang | Department of Acupuncture and Moxibustion and Massage, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China | | HU Aifang | Department of Rheumatology and Immunology, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China | | YANG Lu | Department of Cardiology, Tangshan Hongci Hospital, Tangshan 063000, China | | LIU Man | Department of Rehabilitation, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China | | WU Ying | Department of Rehabilitation, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China | | WANG Rui | Department of Rehabilitation, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China |
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| Abstract
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| [Objective] To explore the clinical efficacy of modified Danggui Niantong Decoction combined with calcium dobesilate tablets in treating diabetes peripheral neuropathy（DPN） and its influence on inflammatory response. [Methods] From January 2023 to June 2024，92 patients with DPN who visited Tangshan Third Hospital were randomly divided into an observation group and a control group，with 46 patients in each group.In addition to basic treatment，the control group was treated with calcium dobesilate tablets，while the observation group was treated with modified Danggui Niantong Decoction in addition to the treatment received by the control group. To compare the efficacy，TCSS score，sensory nerve conduction velocity（SNCV），motor nerve conduction velocity（MNCV），fasting blood glucose（FPG），glycated haemoglobin（HbA1c），haematological rheological indexes，interleukin-6（IL-6），tumour necrosis factor-alpha（TNF-alpha），and C-reactive protein（CRP） between the two groups of patients before and after treatment. [Results] The therapeutic efficacy of the observation group was better（P＜0.05）. After treatment，the TCSS score，FPG，HbA1c，fibrinogen，whole blood low shear viscosity，plasma viscosity，whole blood high shear viscosity，serum IL-6，TNF-α，CRP levels in both groups were significantly decreased，while the SNCV and MNCV of the median and common peroneal nerves were prominently increased，and the observation group was better（P＜0.05）. [Conclusion] The combination of modified Danggui Niantong Decoction and calcium dobesilate tablets has a great effect on DPN patients，it is beneficial for reducing blood glucose levels，improving nerve conduction velocity and hemorheological indicators，and alleviating inflammatory response. |
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