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| Protective effects and mechanisms of Qishen Yiqi Dripping Pills on multi-organ injury in low-pressure hypoxia rats |
| Hits 237 Download times 36 Received:October 01, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.03.13 |
| Key Words
Qishen Yiqi Dripping Pills;acute mountain sickness;AQP4;HIF-1α;VEGFR2 |
| Author Name | Affiliation | E-mail | | XU Guangjing | Military Pharmacy Teaching and Research Office, Logistics College of the People's Armed Police Force, Tianjin 300309, China
School of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Xiaoyu | Military Pharmacy Teaching and Research Office, Logistics College of the People's Armed Police Force, Tianjin 300309, China
School of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JI Yansu | Pharmacy Department, Armed Police Characteristic Medical Centre, Tianjin 300162, China | | | LI Xia | Military Pharmacy Teaching and Research Office, Logistics College of the People's Armed Police Force, Tianjin 300309, China | | | LIU Rui | School of Traditional Chinese Medicine Pharmaceutical Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | liurui@tjutcm.edu.cn | | JIN Xin | Military Pharmacy Teaching and Research Office, Logistics College of the People's Armed Police Force, Tianjin 300309, China | jinxin1227@126.com |
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| Abstract
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| [Objective] To establish a rat model of acute mountain sickness（AMS） and investigate the protective effect of Qishen Yiqi Dripping Pills on multi-organ damage in rats with low-pressure hypoxia and its molecular mechanism. [Methods] After different doses of Qishen Yiqi Dripping Pills were administered for 7 days，the AMS rat model was prepared in a low-pressure oxygen chamber simulating an altitude of 8 000 m. Brain and lung wet-dry weight ratios were detected，cardiac function was evaluated by small animal ultrasound，lung function was determined by pulmonary function meter，blood-brain barrier permeability was detected by Evans blue staining，serum SOD and MDA levels were detected by biochemical kit，and pathological changes in the heart，brain，and lungs were observed by HE staining. Immunohistochemical staining was used to analyse the expression level of AQP4 protein in brain and lung tissues，and Western blot detected the expression of HIF-1α and VEGFR2 protein in brain and lung tissues. [Results] Qishen Yiqi Dripping Pills reduced the degree of brain and lung oedema，improved cardiopulmonary function，lowered the permeability of blood-brain barrier，inhibited oxidative stress，and ameliorated the pathological damage of brain and lung tissues caused by hypoxia in AMS rats. The expression of AQP4，HIF-1α，and VEGFR2 proteins was significantly elevated in the brain and lung tissues of AMS rats，and Qishen Yiqi Dripping Pills markedly inhibited this elevation. [Conclusion] Qishen Yiqi Dripping Pills has a protective effect on organ damage in heart，brain and lung tissues of AMS rats，and may act through the HIF-1α/VEGF and AQP4 pathways. |
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