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| Research progress on the mechanism of acupuncture and combined treatment regulating cAMP-PKA-CREB pathway to improve mild cognitive impairment |
| Hits 1018 Download times 39 Received:August 26, 2025 |
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| DOI
10.11656/j.issn.1672-1519.2026.03.16 |
| Key Words
mild cognitive impairment;cAMP/PKA/CREB signaling pathway;acupuncture and moxibustion;rehabilitation;Alzheimer’s disease |
| Author Name | Affiliation | E-mail | | WANG Zhaoyu | Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | JING Jiayi | Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China | | | ZHAO Guodong | Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | ZHANG Miao | NO. 10 Acupuncture and Moxibustion Department, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China | 13845088833@139.com |
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| Abstract
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| Mild cognitive impairment（MCI） is a transitional state between normal aging and Alzheimer’s disease（AD）. Acupuncture and combined treatment mainly treat MCI by reducing amyloid β-protein（Aβ） deposition，inhibiting hyperphosphorylation of Tau protein，inhibiting neuroinflammation and inhibiting oxidative stress. The cyclic adenosine monophosphate（cAMP）-protein kinase A（PKA）-cAMP responsive element binding protein（CREB） pathway has the characteristics of multi-link，multi-pathway and multi-target regulation of MCI，which is closely related to the improvement of neurodegenerative changes by acupuncture and combined treatment. Based on the cAMP/PKA/CREB signaling pathway，this paper reviews the related mechanisms of acupuncture and combined therapy in the prevention and treatment of MCI，in order to provide ideas for basic and clinical research on MCI in the future. |
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