| 摘要: |
| 目的:观察丹酚酸B(SalB)对肿瘤坏死因子α(TNF-α)损伤大鼠微血管内皮细胞(CMEC)的影响。方法:采用CMEC的体外培养技术,建立TNF-α损伤的模型,观察乳酸脱氢酶(LDH)活性、内皮素(ET)及丙二醛(MDA)含量的变化以及SalB的保护作用。结果:SalB可显着降低LDH活性及MDA含量,有减少ET分泌的趋势。结论:SalB对TNF-α损伤的CMEC具有直接保护作用,其作用可能与其稳定细胞膜、抗脂质过氧化有关。 |
| 关键词: 丹酚酸B 肿瘤坏死因子α 微血管内皮细胞 |
| DOI：10.11656/j.issn.1672-1519.2002.06.21 |
| 分类号: |
| 基金项目:国家重点基础研究发展规划“973”项目资助(No.1999054403) |
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| Effect of SalB on Rats’ CMEC Injured by TNF-α |
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Zhang Meng,Du Rong,Guo Liping
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Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| Objective: To observe the influence of SalB on rats’ CMEC injured by TNF-α. Method: The technique of culture in vitro for CMEC was used and the model induced by TNF-α was established. The indexes including content of LDH, ET and MDA and the protective effect of SalB were observed. Result: SalB could lower the activity of LDH and the content of MDA and had a tendency of lower the secretion of ET. Conclusion: SalB has a direct protective effect on CMEC injured by TNF-α. Its mechanism can be associated with the effects of stabilizing cell membrane and inhibiting lipid peroxidation. |
| Key words: SalB TNF-α CMEC |
