糖肾清I号治疗糖尿病肾病临床研究

Clinical effect of TangshenqingⅠon diabetic nephropathy

关键词:  糖肾清I号  糖尿病肾病  临床研究

Key words:  TangshenqingⅠ  diabetic nephropathy  clinical research

摘要:

[目的]通过临床分组对比研究自拟中药方剂糖肾清I号治疗糖尿病肾病(DN)的疗效。[方法]40例糖尿病肾病随机分为开搏通治疗组(A组)及糖肾清治疗组(B组),在开搏通等基础治疗上,B组加用糖肾清I号2个疗程,治疗前后检测血糖、血脂、血肌酐、血尿素氮、肌酐清除率、β2-微球蛋白、24h尿白蛋白、24h尿蛋白等指标,并做上述结果的均数比较及t检验。[结果]糖肾清及开搏通组,均可使早期DN尿微量蛋白及临床期DN尿蛋白下降(P<0.05),但糖肾清组疗效好于开搏通组(P<0.01).糖肾清可使早期DN肌酐清除率下降(P<0.05),使临床期DN肌酐清除率上升(P<0.05);使临床期DN随机尿β2-MG下降(P<0.05);降低早期及临床期DN的胆固醇及甘油三酯,并可升高高密度脂蛋白(P<0.05)。[结论]糖肾清I号合用基础治疗DN疗效好于单纯应用基础治疗。

Abstract:

[Objective] To research the therapeutic effect of TangshenqingⅠon diabetic nephropathy(DN). [Method] Forty patients were divided into group A(given Captopril)and group B(given Captopril and TangshenqingⅠ)randomly.Before and after treatment blood sugar,blood-lipid,blood creatinine,blood urea nitrogen,creatinine clearance rate(Cr),β₂-microglobulin(β₂-MG),urinary albumin/24h and urinary protein/24h were detected.t-test was used for statistic analy-sis. [Result] Early urinary microprotein and clinical urinary protein of DN were lowered in both groups(P<0.05)and more obvious in group B(P<0.01).TangshenqingⅠcould decrease Cr at early stage(P<0.05).It could also lower cholesterol,triglyceride and enhance HDL concentration(high density lipoprotein)(P<0.05). [Conclusion] TangshenqingⅠassociated with basic treatment Captopril has a better effect than basic treatment only.