针刺对快速老化脑萎缩及痴呆模型小白鼠(SAMP10)行为学影响的实验研究

Effect of acupuncture on senescence accelerate mouse P10(SAMP10)behavior in experimental research

关键词:  快速老化脑萎缩及痴呆模型小鼠(SAMP10)  行为学  “醒脑开窍”针法  “调补气血”针法

Key words:  SAMP10  behavior medicine  Xingnao Kaiqiao  regulating and supplementing qi and blood

摘要:

[目的]研究“醒脑开窍”针法和“调补气血”针法对SAMP10行为学异常改变的影响。[方法]采用自然快速老化脑萎缩及痴呆模型小鼠SAMP10,于实验前后各进行1次穿梭箱实验,并记录小鼠遭受电击次数、电击时间及主动反应时间。[结果]实验前,6月龄P10与R1相比,各行为学指标均有显着性差异(P<0.01);P10各组之间无显着性差异(P>0.05);实验后,醒脑组、补气血组各项指标与P10对照组比较,均有明显改善(P<0.05,或P<0.01),与R1比较,均有显着性差异(P<0.01),而两种针法间比较,无显着差异(P>0.05)。[结论]P10较同月龄R1学习记忆能力显着下降,是理想的脑萎缩及痴呆动物模型。“醒脑开窍”针法和“调补气血”针法可部分改善SAMP10的学习记忆能力。

Abstract:

[Objective] To research the influence of 2 methods of Xingnao Kaiqiao(awaking brain and open orifice)and regulating and supplementing qi and blood on behavior of SAMP10. [Method] Experiment of Shuttle to and fro was done before and after treatment.Times,and interval of received electric attack and times of active reactive movement of SAMP10were recorded. [Result] Before and after treatment all behavior indexes showed a marked difference between SAMP10 and SAMR1,which were6months,(P<0.01).No difference was found between each group of P10(P>0.05).All the indexes in Xingnao Kaiqiao group and regulating and supplementing qi and blood group were improved obviously(P<0.05,P<0.01)with a marked difference with each R1 group(P<0.01).There were no differences between these 2 methods(P>0.05). [Conclusion] P10is a better animal model for SAM than R1since its study and memory ability is lowered than animals of same age.Both of these 2 treatments can improve the ability of SAMP10.