| 摘要: |
| [目的]研究快速老化SAMP10小鼠脑细胞端粒的增龄性变化。[方法]以快速老化模型小白鼠SAMP10为脑老化动物模型,采用Southern杂交方法,测定了不同月龄SAMR1和SAMP10小鼠脑细胞端粒的变化情况。[结果]SAM的细胞端粒长度在17～25kb之间,SAMP10小鼠脑细胞端粒具有随增龄而减少的趋势。[结论]从SAMR1和SAMP10小鼠脑细胞端粒的变化来看,细胞端粒缩短与老化存在着显著的相关性。 |
| 关键词: SAMP10小鼠 脑细胞端粒 增龄性变化 |
| DOI：10.11656/j.issn.1672-1519.2003.05.13 |
| 分类号: |
| 基金项目:国家自然科学基金资助项目 (39800197) |
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| Age-related changes in telomere of brain cell in SAMP10 |
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WANG Shu, DONG Cheng-chao, LU Bin
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The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the age-related changes in telomere of brain cell of mice with brain aging animal.[Methods] SAMP10 was taken as as brain aging animal model. The Southern hybridization was used to measure the changes in telmere of brain cell in different month-age between SAMR1 and SAMP10.[Results] The length of telomere in SAM was 17～25 kb and there was a decreasing trend in brain cell telomere of SAMP 10 while aging.[Conclusion] The contraction of cell telomere has a marked correlation to senile. |
| Key words: SAMP10 mouse telomere of brain cell aged-related change |
