| 摘要: |
| [目的]探讨调肝导浊中药对实验性动脉粥样硬化(AS)家兔模型血小板源性生长因子A链(PDGF-A)及其受体(PDGFR-α)表达的影响,以阐明其抗动脉粥样硬化的作用机制。[方法]采用高胆固醇饮食饲喂家兔,并在饲喂过程中依分组进行不同处理。实验结束后,处死动物取主动脉,用免疫组化方法检测PDGF-A、PDGFR-α的表达。[结果]AS模型组家兔主动脉PDGF-A、PDGFR-α阳性表达增强,而调肝导浊中药可有效降低其表达。[结论]调肝导浊中药可有效抑制高胆固醇饮食诱导的PDGF-A、PDGFR-α表达增强,从而阻止AS的发生发展。 |
| 关键词: 调肝导浊 动脉粥样硬化 血小板源性生长因子(PDGF-A) 受体(PDGFR-α) 免疫组化 |
| DOI：10.11656/j.issn.1672-1519.2003.05.33 |
| 分类号: |
| 基金项目:天津市高等学校科技发展基金资助课题(项目编号:991214) |
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| Influence of Chinese medicine Tiaogan Daozhuo Decoctionon on PDGF-A and PDGFR-αexpression in rabbits with AS |
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ZHANG Hong_xia,LI Guang_bin,JIANG Xi_juan
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Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the effect of Chinese medicine Tiaogan Daozhuo Decoction on PDGF-A and PDGFR-α expression in rabbits with AS.[Methods] The rabbits were fed with cholesterol-rich diet and underwent different management in each group simultaneously.The aorta was obtained for immunohistochemical examination at the end of experiment.[Results] In the model group, the aorta showed a heavily pathological changes of AS. And the positive expression of PDGF-A and PDGFR-α increased markedly. Tiaogan Daozhuo Decoction could inhibit the expression effectively.[Conclusion] Tiaogan Daozhuo Decoction can prevent the formation and progress of AS by inhibiting the increased expression of PDGF-A and PDGFR-αinduced by cholesterol-rich diet. |
| Key words: PDGF receptor immunohistochemistry |
